Schizoaffective disorder: A form of schizophrenia or affective disorder?
Schizoaffective disorder: A form of schizophrenia or affective disorder?
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DOI：
10.4088/jcp.v60n1211
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发表时间：
1999-12-01
影响因子：
5.3
通讯作者：
Jeste, DV
中科院分区：
文献类型：
--
作者：
Evans, JD;Heaton, RK;Jeste, DV
背景：分裂情感性障碍的诊断状态仍然存在争议。研究人员提出，精神分裂情感性障碍代表了精神分裂症或情感性障碍的一种变体，是两者的组合，或者是精神分裂症和情感性障碍之间的连续体的中间状态。方法：我们比较了年龄在 45 至 77 岁之间、经 DSM-III-R 诊断为精神分裂性情感性障碍 (N = 29)、精神分裂症 (N = 154) 或根据精神病理学标准化评定量表和综合神经心理学测试组，非精神病性情绪障碍（N = 27）。判别函数分析用于根据精神分裂症患者的神经心理学特征将分裂情感性患者分类为与精神分裂症患者或非精神病性情绪障碍患者相似。结果：分裂情感性和精神分裂症患者有更严重的运动障碍，情绪障碍家族史较弱，因精神原因住院的频率更高，更有可能服用抗精神病药和抗胆碱能药物与情绪障碍患者相比，抑郁症状的严重程度有所减轻。精神分裂症患者比分裂情感和情绪障碍患者有更严重的阳性症状。两个精神病组的神经心理学表现比非精神病性情绪障碍患者受损更严重。最后，根据判别函数分析，分裂情感性患者比情绪障碍更有可能被归类为精神分裂症。结论：这些发现表明，分裂情感性障碍可能代表精神分裂症的临床症状特征和认知障碍的一种变体。
Background: The diagnostic status of schizoaffective disorder continues to be controversial. Researchers have proposed that schizoaffective disorder represents a Variant of schizophrenia or affective disorder, a combination of the 2, or an intermediate condition along a continuum between schizophrenia and affective disorder.Method: We compared outpatients aged 45 to 77 years with DSM-III-R diagnosis of schizoaffective disorder (N = 29), schizophrenia (N = 154), or nonpsychotic mood disorder (N = 27) on standardized rating scales of psychopathology and a comprehensive neuropsychologi cal test battery. A discriminant function analysis was used to classify the schizoaffective patients based on their neuropsychological profiles as being similar either to schizophrenia patients or to those with nonpsychotic mood disorder.Results: The schizoaffective and schizophrenia patients had more severe dyskinesia, had a weaker family history of mood disorder, had been hospitalized for psychiatric reasons more frequently, were more likely to be prescribed neuroleptic and anticholinergic medication, and had somewhat less severe depressive symptoms than the mood disorder patients. The schizophrenia patients had more severe positive symptoms than the schizoaffective and mood disorder patients. The neuropsychological performances of the 2 psychosis groups were more impaired than those of the nonpsychotic mood disorder patients. Finally, on the basis of a discriminant function analysis, the schizoaffective patients were more likely to be classified as having schizophrenia than a mood disorder.Conclusion: These findings suggest that schizoaffective disorder may represent a variant of schizophrenia in clinical symptom profiles and cognitive impairment.