COMT Val108/158Met polymorphism and the modulation of task-oriented behavior in children with ADHD.
COMT Val108/158Met polymorphism and the modulation of task-oriented behavior in children with ADHD.
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COMT Val108/158Met 多态性和 ADHD 儿童任务导向行为的调节。
DOI：
10.1038/npp.2008.85
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Joober,Ridha
中科院分区：
文献类型：
--
作者：
Sengupta,Sarojini;Grizenko,Natalie;Schmitz,Norbert;Schwartz,George;Bellingham,Johanne;Polotskaia,Anna;Stepanian,MarinaTer;Goto,Yukiori;Grace,AnthonyA;Joober,Ridha
It has been suggested that the symptoms of attention-deficit/hyperactivity disorder (ADHD), including inattention and/or hyperactivity/impulsivity, translate into deficits in task-oriented behavior or problem-focused activity. The frontosubcortical dopamine pathway has been implicated in ADHD. One of the key modulators of extracellular dopamine levels in the prefrontal cortex is catechol-O-methyltransferase (COMT). The objective of this study was to examine the association of the COMT Val 108/158 Met polymorphism with (1) task-oriented behavior in children with ADHD, and (2) response of this behavior given methylphenidate (MPH) treatment. Children of Caucasian ethnicity, having ADHD (n= 188), were assessed using the Restricted Academic Situation Scale (RASS). The RASS uses a simulated academic environment within the research clinic, to assess the child's ability for independent, sustained orientation to an assignment of math problems. Each child was administered placebo and MPH (0.5 mg/kg in a divided bid dose), each for a 1-week period, in a randomized, double-blind, crossover trial. On day 3 of the respective treatment week, the child was administered placebo/MPH in the clinic, and the acute change in behavior (before and 1 h after treatment) was evaluated on the RASS. Analysis was carried out using mixed model analysis of variance. Significant main effects of COMT genotype (F 2,184= 5.12, p= 0.007) and treatment (F 1,184= 44.26, p< 0.001) on task-oriented behavior were observed. However, no genotype by treatment interaction was observed. These results suggest that the COMT Val 108/158 Met polymorphism modulates task-oriented behavior, but it does not modulate the response of this behavior with MPH treatment.
