Peroxide bond-dependent antiplasmodial specificity of arternisinin and OZ277 (RBx11160)
Peroxide bond-dependent antiplasmodial specificity of arternisinin and OZ277 (RBx11160)
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DOI：
10.1128/aac.00225-07
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发表时间：
2007-08-01
影响因子：
4.9
通讯作者：
Vennerstrom, Jonathan L.
中科院分区：
文献类型：
--
作者：
Kaiser, Marcel;Wittlin, Sergio;Vennerstrom, Jonathan L.
使用青蒿素和OZ277（R &11160）的非过氧化物类似物，后两种化合物的强体外抗疟原虫活性显示为过氧化物键依赖性的。相反，青蒿素和OZ277对其他六种原生动物寄生虫的弱活性是不依赖于过氧化物键的。这些数据支持铁依赖性青蒿素烷基化假说。
Using nonperoxidic analogs of artemisinin and OZ277 (R&11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.