Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells
Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells
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DOI：
10.7554/elife.23661
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发表时间：
2017-03-07
期刊：
影响因子：
7.7
通讯作者：
Wu, Doris K.
中科院分区：
文献类型：
--
作者：
Jiang, Tao;Kindt, Katie;Wu, Doris K.
机械感觉毛细胞（HC）顶面上的静纤毛束（毛束）的不对称位置决定了给定HC对声音、头部运动和水压等线索的反应方向。值得注意的是，内耳的前庭感觉器官（黄斑）表现出极性反转线（LPR），毛束以镜像模式极化。同样，在斑马鱼侧线系统的神经乳突中的毛细胞是成对产生的，并且两个兄弟毛细胞发展成相反的毛束方向。在这些感觉器官中，转录因子Emx 2的表达仅限于黄斑中LPR的一侧或神经瘤中两个兄弟HC之一。Emx2介导毛束极性逆转在这些限制性的HC的子集，并产生镜像模式的感觉器官。Emx2的下游效应子通过异源三聚体G蛋白自主控制束极性细胞。
The asymmetric location of stereociliary bundle (hair bundle) on apical surface of mechanosensory hair cells (HCs) dictates the direction in which a given HC can respond to cues such as sound, head movements, and water pressure. Notably, vestibular sensory organs of the inner ear, the maculae, exhibit a line of polarity reversal (LPR) across which, hair bundles are polarized in a mirror-image pattern. Similarly, HCs in neuromasts of the zebrafish lateral line system are generated as pairs, and two sibling HCs develop opposite hair bundle orientations. Within these sensory organs, expression of the transcription factor Emx2 is restricted to only one side of the LPR in the maculae or one of the two sibling HCs in neuromasts. Emx2 mediates hair bundle polarity reversal in these restricted subsets of HCs and generates the mirror-image pattern of the sensory organs. Downstream effectors of Emx2 control bundle polarity cell-autonomously via heterotrimeric G proteins.