Non-linear mixed effects models for the evaluation of dissolution profiles
Non-linear mixed effects models for the evaluation of dissolution profiles
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DOI：
10.1016/s0378-5173(02)00127-8
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发表时间：
2002-06-20
影响因子：
5.8
通讯作者：
Massart, DL
中科院分区：
文献类型：
--
作者：
Adams, E;Coomans, D;Massart, DL
已经评估了使用非线性混合效应模型来描述溶出数据，其中包括理论部分，以向不熟悉此类统计数据的科学家介绍这种方法。尽可能使用统计软件包（S-plus）的标准设置。采用威布尔、逻辑、一阶和 Gompertz 等多种数学函数作为非线性混合效应模型的基础。使用立即释放片剂和缓释片剂的溶出度数据给出示例，将结果与使用线性混合效应模型获得的结果进行比较。 (C) 2002 爱思唯尔科学 B,V。版权所有。
The use of non-linear mixed effects models to describe dissolution data has been evaluated, A theoretical part is included to introduce this approach to scientists who are not Familiar with this type of statistics. The standard settings of the statistical software package (S-plus) are used as much as possible. Several mathematical functions like the Weibull, logistic, first-order and Gompertz are employed as basis for the non-linear mixed effects models. Examples are given using dissolution data of immediate and extended release tablets, The results are compared with those obtained using linear mixed effects models. (C) 2002 Elsevier Science B,V. All rights reserved.