Sol-gel-processed silica/polydimethylsiloxane/calcium xerogels as polymeric matrices for Metronidazole delivery system
Sol-gel-processed silica/polydimethylsiloxane/calcium xerogels as polymeric matrices for Metronidazole delivery system
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DOI：
10.1007/s00289-010-0332-8
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发表时间：
2011-01-01
期刊：
影响因子：
3.2
通讯作者：
Czarnobaj, Katarzyna
中科院分区：
文献类型：
--
作者：
Czarnobaj, Katarzyna
研究了二氧化硅、二氧化硅/聚二甲基硅氧烷和二氧化硅/聚二甲基硅氧烷/钙干凝胶作为药物甲硝唑控释的聚合物载体。表征分析包括通过傅里叶变换红外光谱 (FTIR) 对基质进行分析、确定固体比表面积 (BET) 和扫描电子显微镜 (SEM) 技术，以及在紫外和可见光区域 (UV-Vis) 中进一步监测药物随时间的体外释放情况。以四甲氧基硅烷（TMOS）为二氧化硅基体前驱体，以聚二甲基硅氧烷（PDMS）和钙离子为添加剂，获得了具有不同形貌和物理性质的干凝胶。应用的修饰降低了二氧化硅基质的孔隙率和亲水性，并减少了药物的释放。根据本研究的结果，可以说应用的干凝胶基质、纯二氧化硅 (SiO2) 和改性二氧化硅（SiO2-CaO、SiO2-PDMS 和 SiO2-CaO-PDMS）可能是局部递送系统制剂的有希望的候选者。
Silica, silica/polydimethylsiloxane and silica/polydimethylsiloxane/calcium xerogels were examined as polymeric carriers for the controlled release of drug-Metronidazole. Characterization assays comprised analysis of the matrix by Fourier transform infrared spectroscopy (FTIR), determining the specific surface area of solids (BET) and scanning electron microscope (SEM) techniques and further monitoring in the ultraviolet and visible light regions (UV-Vis) of the in vitro release of the drug over time. Using tetramethoxysilane (TMOS) as a precursor of silica matrix and polydimethylsiloxane (PDMS) and calcium ions as additives, xerogels with different morphology and physical properties were obtained. The applied modifications diminished the porosity and hydrophilicity of the silica matrix as well as reduced the release of drug. Based on the presented results of this study, it may be stated that applied xerogel matrices, pure silica (SiO2) and modified silica (SiO2-CaO, SiO2-PDMS and SiO2-CaO-PDMS), could be promising candidates for the formulation in local delivery systems.