Multimodal optical imaging for simultaneous in-vivo morphological and biochemical characterization of oral epithelial cancer.
Multimodal optical imaging for simultaneous in-vivo morphological and biochemical characterization of oral epithelial cancer.
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多模态光学成像可同时表征口腔上皮癌的体内形态学和生化特征。
DOI：
10.1109/iembs.2010.5627569
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Jo,JavierA
中科院分区：
文献类型：
--
作者：
Shrestha,Sebina;Park,Jesung;Pande,Paritosh;Applegate,BrianE;Jo,JavierA
癌症的早期发现是降低发病率和死亡率的关键。形态和化学生物标志物预示着从正常组织向癌变组织的转变。我们开发了一种结合光学相干层析成像和荧光寿命成像的非侵入性成像系统，以获取这两组生物标志物。在这里，我们报告了一项动物研究的早期有利结果，该研究旨在衡量这种方法在口腔癌早期诊断中的能力。
Early detection of cancer is key to reducing morbidity and mortality. Morphological and chemical biomarkers presage the transition from normal to cancerous tissue. We have developed a noninvasive imaging system incorporating optical coherence tomography and fluorescence lifetime imaging to acquire both sets of biomarkers. Here we report early favorable results from an animal study designed to measure the capacity of this approach for early diagnosis of oral cancer.