Polymorphism in the promoter of the gene for the serotonin transporter affects the age of onset of major depressive disorder in the Japanese population.
Polymorphism in the promoter of the gene for the serotonin transporter affects the age of onset of major depressive disorder in the Japanese population.
复制标题
血清素转运蛋白基因启动子的多态性影响日本人群重度抑郁症的发病年龄。
DOI：
10.1016/j.jad.2015.05.009
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Ohmori T.
中科院分区：
文献类型：
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作者：
Watanabe SY;Iga J;Numata S;Umehara H;Nishi A;Kinoshita M;Inoshita M;Ohmori T.
最近的研究表明，5-羟色胺转运蛋白基因（5-羟色胺转运蛋白连锁多态性区域，5 HTTLPR）的启动子区域的功能多态性可能与基因-环境相互作用导致重度抑郁症（MDD）。我们在216例MDD患者和213年龄和性别匹配的controls.ResultsThe基因型分布和等位基因频率在患者和对照组中是相似的5 HTTLPR基因型。当多态性和几个临床变量之间的关系（即，发病年龄、发作次数、精神病特征、自杀行为和家族史）进行了检查，长（1）等位基因的剂量对发病年龄有显著影响。结论这些结果表明，5 HTTLPR可能与MDD的发生不完全相关，但可能与MDD的发病年龄有关，这可能是由于日本人群中的基因-环境相互作用。局限性由于精神病特征和自杀行为的频率较低，我们的结果必须谨慎对待，直到它们在更大数量的日本样本中重复。MDD患者未接受结构化访谈。病历中的临床信息可能不完整。
ObjectiveRecent research has suggested that a functional polymorphism in the promoter region of the serotonin transporter gene (serotonin transporter-linked polymorphic region, 5HTTLPR) may be implicated in gene–environment interactions leading to major depressive disorder (MDD).MethodsOur study examined the association between 5HTTLPR and clinical variables of MDD in the Japanese population. We genotyped 5HTTLPR in 216 patients with MDD and 213 age- and sex-matched controls.ResultsThe genotype distributions and allele frequencies were similar in the patients and controls. When the relationships between the polymorphism and several clinical variables (i.e., age of onset, number of episodes, presence of psychotic features, suicidal behavior, and family history) were examined, the dose of the long (l) allele had significant effects on the age of onset.ConclusionThese results suggest that 5HTTLPR may not be entirely related to the development of MDD but may be related to the age of onset of MDD, which may be due to gene–environment interactions in the Japanese population.LimitationsBecause of the low frequencies of psychotic features and suicidal behavior, our results must be treated with caution until they are replicated in larger numbers of Japanese samples. MDD patients did not undergo a structured interview. Clinical information from the medical records may have not been complete.