A systematic review of pediatric adherence to antiretroviral therapy in low- and middle-income countries
A systematic review of pediatric adherence to antiretroviral therapy in low- and middle-income countries
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DOI：
10.1097/inf.0b013e31816dd325
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发表时间：
2008-08-01
影响因子：
3.6
通讯作者：
Nvandiko, Winstone M.
中科院分区：
文献类型：
--
作者：
Vreeman, Rachel C.;Wiehe, Sarah E.;Nvandiko, Winstone M.
背景资料：维持抗逆转录病毒疗法的坚持需要准确、一致的监测，这对低收入国家来说是一个特别的挑战。最佳策略，以衡量儿科adherence.Objective：进行系统的审查，儿科ART坚持测量技术，坚持估计，并在低收入和中等收入国家的临床相关性，以告知ART adherencemonitoring.Methods：我们搜索在线书目数据库，包括MEDLINE和EMBASE，使用系统的标准。两名评审员选择了所有涉及非妊娠、HIV阳性个体的描述性或干预性研究，依从性75%。与家庭结构，社会经济地位，披露和药物治疗方案相关的因素都与ART adherence.Conclusions显着相关：在低收入和中等收入国家的儿科艾滋病护理计划使用异质性的方法来衡量ART的坚持。依从性估计值差异很大，但来自低收入和中等收入国家的大多数研究报告依从性> 75%，而来自高收入国家的大多数研究报告依从性< 75%。
Background: Sustaining antiretroviral therapy (ART) adherence requires accurate, consistent monitoring, a particular challenge for low-income countries. The optimal strategy to measure pediatric adherence remains unclear.Objective: To conduct a systematic review of pediatric ART adherence measurement techniques, adherence estimates, and clinical correlates in low-and middle-income countries to inform ART adherence monitoring.Methods: We searched online bibliographic databases, including MEDLINE and EMBASE, using systematic criteria. Two reviewers selected all descriptive or interventional studies involving nonpregnant, HIV-positive individuals 75% adherence. Factors related to family structure, socioeconomic status, disclosure, and medication regimen were all significantly associated with ART adherence.Conclusions: Pediatric HIV care programs in low- and middle-income countries use heterogeneous methods to measure ART adherence. Adherence estimates vary substantially, but most studies from low- and middle-income countries report > 75% adherence, whereas most studies from high-income countries report < 75% adherence.