Intrahepatic cholangiocarcinoma arising in chronic advanced liver disease and the cholangiocarcinomatous component of hepatocellular cholangiocarcinoma share common phenotypes and cholangiocarcinogenesis
Intrahepatic cholangiocarcinoma arising in chronic advanced liver disease and the cholangiocarcinomatous component of hepatocellular cholangiocarcinoma share common phenotypes and cholangiocarcinogenesis
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DOI：
10.1111/j.1365-2559.2011.04058.x
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发表时间：
2011-12-01
期刊：
影响因子：
6.4
通讯作者：
Nakanuma, Yasuni
中科院分区：
文献类型：
--
作者：
Xu, Jing;Sasaki, Motoko;Nakanuma, Yasuni
目的：肝内胆管细胞癌（ICC）是已知的情况下，非胆管，慢性晚期肝病（CALD），但其临床病理特征仍然没有探索。本研究的目的是比较组织学和免疫组化的ICC发生在CALD与肝脏发生的非特异性反应（NSR）的changes.Methods和结果：ICC发生在CALD的71例发生在肝脏NSR的变化，包括正常肝脏（72例）和肝细胞性胆管癌（HC-CCs）的胆管癌（CC）的组成部分（30例）进行了比较。粘液在伴有NSR改变的ICC中表达较高，而在伴有CALD的ICC和HC-CC的CC组分中表达相对较低。胆管标志物[细胞角蛋白（CK）7，CK 19，上皮细胞膜抗原，上皮细胞粘附分子（EpCAM）]的表达在CC与CALD和在CC组件的HC-CC比在CC与NSR的变化。肝祖细胞标志物神经细胞粘附分子（NCAM）和c-kit在伴有CALD的ICC和HC-CC的CC组分中的表达高于伴有NSR改变的ICC。EpCAM和CK 19不断表达在培养的CC细胞，而NCAM很少表达在培养的CC cells.Conclusions：癌的发生ICC引起的CALD和ICC组成部分的HC-CC，每个显示出类似的功能，可能涉及肝祖细胞。
Aims: Intrahepatic cholangiocarcinomas (ICCs) are known to arise in cases of non-biliary, chronic advanced liver disease (CALD), but their clinicopathological features remain unexplored. The aim of this study was to compare the histological and immunohistochemical ICCs arising inCALD with those arising in livers with non-specific reactive (NSR) changes.Methods and results: Seventy-one cases of ICC arising in CALD were compared with ICCs arising in livers with NSR changes, including normal livers (72 cases) and the cholangiocarcinomatous (CC) component of hepatocellular cholangioncarcinomas (HC-CCs) (30 cases). The expression of mucin was higher in ICC with NSR changes, whereas it was relatively low in ICC with CALD and the CC component of HC-CC. The expression of biliary markers [cytokeratin (CK) 7, CK19, epithelial membrane antigen, and epithelial cell adhesion molecule (EpCAM)] was lower in CC with CALD and in the CC component of HC-CC than in CC with NSR changes. The expression of hepatic progenitor cell markers [neural cell adhesion molecule (NCAM) and c-kit] was higher in ICC with CALD and the CC component of HC-CC than in ICC with NSR changes. EpCAM and CK19 were constantly expressed in cultured CC cells, whereas NCAM was infrequently expressed in cultured CC cells.Conclusions: The carcinogenesis of ICC arising in CALD and the ICC component of HC-CC, each showing similar features, may involve hepatic progenitor cells.