Finding the right control: The mismatch negativity under investigation
Finding the right control: The mismatch negativity under investigation
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DOI：
10.1016/j.clinph.2011.07.035
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发表时间：
2012-03
影响因子：
4.7
通讯作者：
P. Ruhnau;Björn Herrmann;E. Schröger
中科院分区：
文献类型：
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作者：
P. Ruhnau;Björn Herrmann;E. Schröger
当研究听觉知觉的规律性加工时，失配负波（MMN）是常用的。MMN被计算为由重复的标准音调和很少发生的异常音调引起的事件相关电位（ERP）之间的差异信号。这个过程导致低估的N1组件引起的标准相比，N1的偏差，可能会影响MMN。因此，先前引入了随机对照设计。然而，这种设计高估了N1的偏差。在这里，我们开发了一个新的范例，避免了以前的缺点。METHODS我们设计了一个定期的级联序列作为一个控制的偏差。在常规oddball阻断（标准、异常）、随机对照阻断和级联对照阻断时测量ERP，在每个差异信号中观察到TSMMN。关于N1，标准引起最小的振幅。异常和级联对照的N1相当。最大的N1引起的随机control.CONCLUSIONStandards低估N1不应期效应的反应偏差，而随机控制音高估。级联控制音，然而，提供了一个合理的估计N1。显著性新的级联控制设计是适合于调查的听觉知觉规律性过程，同时控制N1不应性效应。
OBJECTIVEWhen investigating auditory perceptual regularity processing, mismatch negativity (MMN) is commonly used. MMN is computed as a difference signal between the event-related potentials (ERPs) elicited by repeated standard tones and rarely occurring deviant tones. This procedure leads to an underestimation of the N1 component elicited by standards compared to the N1 to deviants which might affect the MMN. Consequently, a random control design was previously introduced. This design, however, overestimates the N1 to the deviant. Here, we developed a new paradigm that avoids previous drawbacks.METHODSWe designed a regular cascadic sequence as a control to the deviant. ERPs were measured while presenting conventional oddball blocks (standards, deviants), random control blocks and a cascadic control block.RESULTSMMN was observed in each difference signal. Regarding the N1, standards elicited smallest amplitudes. The N1 for the deviant and the cascadic control was comparable. The largest N1 was elicited by the random control.CONCLUSIONStandards underestimate N1 refractoriness effects in the responses to deviants, while random control tones overestimate. Cascadic control tones, however, provide a reasonable estimation for the N1.SIGNIFICANCEThe new cascadic control design is suitable to investigate auditory perceptual regularity processes while controlling for N1 refractoriness effects.