Caveolae and lipid trafficking in adipocytes.
Caveolae and lipid trafficking in adipocytes.
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DOI：
10.2217/clp.10.80
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发表时间：
2011
影响因子：
--
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Pilch PF;Meshulam T;Ding S;Liu L
脂肪细胞中大量的小窝表明这些结构可能具有细胞特异性作用，并且由于这些细胞摄取和释放脂肪酸作为其定量上最稳健的活性，因此脂肪酸运动的调节是由大量体外和体内数据支持的一种这样的作用。此外，小窝特别富含胆固醇和鞘脂，事实上，脂肪细胞比任何其他组织都含有更多的胆固醇。在这篇文章中，我们回顾了脂肪细胞小窝的作用，这些重要的脂质类。
The abundance of caveolae in adipocytes suggests a possible cell-specific role for these structures, and because these cells take up and release fatty acids as their quantitatively most robust activity, modulation of fatty acid movement is one such role that is supported by substantial in vitro and in vivo data. In addition, caveolae are particularly rich in cholesterol and sphingolipids, and indeed, fat cells harbor more cholesterol than any other tissue. In this article, we review the role of adipocyte caveolae with regard to these important lipid classes.