Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial
Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial
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DOI：
10.1016/j.clnu.2015.05.003
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发表时间：
2016-06-01
影响因子：
6.3
通讯作者：
Hsu, Chung-Hua
中科院分区：
文献类型：
--
作者：
Chen, I-Ju;Liu, Chia-Yu;Hsu, Chung-Hua
背景和目的：检查每日剂量 856.8 毫克的高剂量绿茶提取物（表没食子儿茶素没食子酸酯，EGCG）对中心性肥胖女性的体重减轻、血脂谱和肥胖相关激素肽的变化的效果和安全性。 NCT02147041。 A total of 115 women with central obesity were screened at our clinic. 102 of them with a body mass index (BMI) >= 27 kg/m(2) and a waist circumference (WC) >= 80 cm were eligible for the study. These women were randomly assigned to either a high-dose green tea group or placebo group.总治疗时间为12周。主要结果指标是人体测量、血脂分布和肥胖相关激素肽，包括瘦素、脂联素、生长素释放肽和胰岛素。 结果：体重显着减轻，从 76.8 +/- 113 公斤减至 75.7 +/- 11.5 公斤（p = 0.025），体重指数（BMI）（p = 0.018）和腰围也有所下降 (p = 0.023) were observed in the treatment group after 12 weeks of high-dose EGCG treatment. This study also demonstrated a consistent trend of decreased total cholesterol, reaching 5.33%, and decreased LDL plasma levels. There was good tolerance of the treatment among subjects without any side effects or adverse events.与安慰剂组相比，研究组检测到的胃饥饿素水平显着降低，脂联素水平显着升高。结论：高剂量绿茶提取物治疗 12 周后，中心性肥胖女性的体重显着减轻，腰围减小，总胆固醇和低密度脂蛋白血浆水平持续下降，且没有任何副作用或不良反应。高剂量绿茶提取物的抗肥胖机制可能部分与抑制生长素释放肽分泌有关，从而导致脂联素水平升高。 (C) 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.版权所有。
Background and aims: To examine the effect and safety of high-dose green tea extract (Epigallocatechin gallate, EGCG) at a daily dosage of 856.8 mg on weight reduction and changes of lipid profile and obesity related hormone peptides in women with central obesity.Methods: We conducted a randomized, double-blind trial registered under ClinicalTrials.gov Identifier no. NCT02147041. A total of 115 women with central obesity were screened at our clinic. 102 of them with a body mass index (BMI) >= 27 kg/m(2) and a waist circumference (WC) >= 80 cm were eligible for the study. These women were randomly assigned to either a high-dose green tea group or placebo group. The total treatment time was 12 weeks. The main outcome measures were anthropometric measurements, lipid profiles, and obesity related hormone peptides including leptin, adiponectin, ghrelin, and insulin.Results: Significant weight loss, from 76.8 +/- 113 kg to 75.7 +/- 11.5 kg (p = 0.025), as well as decreases in BMI (p = 0.018) and waist circumference (p = 0.023) were observed in the treatment group after 12 weeks of high-dose EGCG treatment. This study also demonstrated a consistent trend of decreased total cholesterol, reaching 5.33%, and decreased LDL plasma levels. There was good tolerance of the treatment among subjects without any side effects or adverse events. Significantly lower ghrelin levels and elevated adiponectin levels were detected in the study group than in the placebo group.Conclusion: 12 weeks of treatment with high-dose green tea extract resulted in significant weight loss, reduced waist circumference, and a consistent decrease in total cholesterol and LDL plasma levels without any side effects or adverse effects in women with central obesity. The antiobestic mechanism of high-dose green tea extract might be associated in part with ghrelin secretion inhibition, leading to increased adiponectin levels. (C) 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.