Directionality index of neural information flow as a measure of synaptic plasticity in chronic unpredictable stress rats
Directionality index of neural information flow as a measure of synaptic plasticity in chronic unpredictable stress rats
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DOI：
10.1016/j.neulet.2010.12.024
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发表时间：
2011-02
影响因子：
2.5
通讯作者：
C. Zheng;Meina Quan;Zhuo Yang;Tao Zhang
中科院分区：
文献类型：
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作者：
C. Zheng;Meina Quan;Zhuo Yang;Tao Zhang
本研究旨在探讨慢性不可预测应激（CUS）动物神经信息流的方向性是否可以作为突触可塑性测量的指标。采用进化图方法（EMA）确定大脑皮层和丘脑之间信息流的方向，并在正常组和应激组Wistar大鼠的相同两个位置记录颅内EEG，诱导丘脑皮层通路的长时程增强。结果表明，应激状态下CUS模型大鼠的耦合方向指数较正常状态下明显偏移，丘脑驱动额叶皮质的强度明显减弱。此外，LTP实验数据显示，慢性应激降低了内侧前额叶皮层（mPFC）突触可塑性，这与EEG结果一致。这些结果表明，用EMA测量神经元信息流的方向性指数可以作为突触可塑性的一个指标。
This investigation examined whether the directionality of neural information flow could be used to index the measurement of synaptic plasticity in the chronic unpredictable stress (CUS) animals. Evolution map approach (EMA) was employed to determine the direction of information flow between the cortex and thalamus, while the experiment was performed by inducing long-term potentiation of the thalamocortical pathway after recording intracranial EEG at the same two positions in Wistar rats of both normal and stressed groups. The results showed that the coupling direction index was significantly diverted in stressed state compared to that in normal state, while the strength of thalamus driving frontal cortex was considerably reduced in the rats of CUS model. Moreover, the data obtained from LTP experiment exhibited that chronic stress decreased medial prefrontal cortex (mPFC) synaptic plasticity, which was certainly in accordance with the EEG findings. These results demonstrated that using EMA measurement, directionality index of neural information flow may be as a measure of synaptic plasticity.