Protocol for WeExPAnd: a prospective, mixed-methods pilot demonstration study to increase access to pre-exposure prophylaxis among women vulnerable to HIV infection in the Southern USA.
Protocol for WeExPAnd: a prospective, mixed-methods pilot demonstration study to increase access to pre-exposure prophylaxis among women vulnerable to HIV infection in the Southern USA.
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DOI：
10.1136/bmjopen-2023-075250
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发表时间：
2023-06-07
期刊：
影响因子：
2.9
通讯作者：
Kempf, Mirjam-Colette
中科院分区：
文献类型：
--
作者：
Psaros, Christina;Goodman, Georgia R.;McDonald, Victoria Wright;Ott, Corilyn;Blyler, Abigail;Rivas, Alexa;Shan, Liang;Campbell, Marquetta;Underwood, Eric;Krakower, Douglas;Elopre, Latesha;Kudroff, Kachina;Sherr, Kenneth H.;Kempf, Mirjam-Colette
非洲裔美国妇女（AA），特别是生活在美国东南部的妇女，艾滋病毒感染率高得不成比例。暴露前预防（PrEP）是一种非常有效的艾滋病毒预防工具，可以绕过传统艾滋病毒预防工具的障碍，例如使用避孕套;然而，对于如何改善可能受益于PrEP使用的AA女性的PrEP获取和吸收知之甚少。该项目旨在了解如何增加美国南部农村AA妇女的PrEP获取，这可能最终影响该人群的艾滋病毒发病率。本研究的目标是系统地调整患者-提供者沟通工具，以增加在亚拉巴马联邦合格的健康中心接受护理的AA妇女的PrEP摄入。我们将使用一个迭代的实施过程，通过评估的可行性，可接受性和初步影响的工具PrEP摄取，使用试点干预前/干预后设计（N=125）。我们将评估女性拒绝转介到PrEP提供者的原因，转介不完整的原因，成功转介后不启动PrEP的原因以及在我们的样本中启动PrEP后3个月和12个月持续使用PrEP的原因。拟议的工作将大大有助于我们了解影响AA妇女中PrEP吸收和使用的因素，特别是在服务不足的地区，这些地区受到艾滋病毒流行的严重影响，并且与美国其他地区相比，艾滋病毒相关的健康结果更差。本方案已获得亚拉巴马大学伯明翰分校（Birmingham，AL;方案300004276）机构审查委员会（IRB）的批准。所有受试者将审查IRB批准的详细知情同意书，并在入组前提供书面或口头知情同意书。将通过同行审查的手稿、报告以及地方、国家和国际介绍来传播成果。NCT 04373551。
African American women (AA), particularly those living in the Southeastern USA, experience disproportionately high rates of HIV infection. Pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention tool that may circumvent barriers to traditional HIV prevention tools, such as condom use; however, very little is known about how to improve PrEP access and uptake among AA women who may benefit from PrEP use. This project aims to understand how to increase PrEP access among AA women in the rural Southern USA, which may ultimately affect HIV incidence in this population. The goal of the current study is to systematically adapt a patient–provider communication tool to increase PrEP uptake among AA women receiving care at a federally qualified health centre in Alabama. We will use an iterative implementation process, by assessing the feasibility, acceptability and preliminary impact of the tool on PrEP uptake, using a pilot preintervention/postintervention design (N=125). We will evaluate women’s reasons for declining a referral to a PrEP provider, reasons for incomplete referrals, reasons for not initiating PrEP after a successful referral and ongoing PrEP use at 3 and 12 months after PrEP initiation among our sample. The proposed work will significantly contribute to our understanding of factors impacting PrEP uptake and use among AA women, particularly in underserved areas in the Deep South that are heavily impacted by the HIV epidemic and experience worse HIV-related health outcomes relative to other areas in the USA. This protocol has been approved by the Institutional Review Board (IRB) at University of Alabama at Birmingham (Birmingham, AL; protocol 300004276). All participants will review a detailed informed consent form approved by the IRB and will provide written or verbal informed consent prior to enrolment. Results will be disseminated through peer-reviewed manuscripts, reports, and local, national and international presentations. NCT04373551.
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影响因子：
4.1
作者：
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通讯作者：
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影响因子：
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影响因子：
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DOI：
10.1097/qai.0b013e3181ab5e10
发表时间：
2009-09-01
影响因子：
3.6
作者：
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影响因子：
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