Resistive Pulse Analysis of Microgel Deformation During Nanopore Translocation.
Resistive Pulse Analysis of Microgel Deformation During Nanopore Translocation.
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纳米孔易位过程中微凝胶变形的电阻脉冲分析。
DOI：
10.1021/jp111244v
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发表时间：
2011-02-24
期刊：
影响因子：
--
通讯作者：
White HS
中科院分区：
文献类型：
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作者：
Holden DA;Hendrickson G;Lyon LA;White HS
通过电阻脉冲方法研究了半径为 570 nm 的聚（N-异丙基丙烯酰胺-丙烯酸）微凝胶穿过玻璃中各个半径为 375 至 915 nm 的纳米孔时的变形。颗粒通过尺寸小于微凝胶的纳米孔的移位产生反映微凝胶变形动态的电信号。易位率、事件持续时间和峰形状是微凝胶和电解质电导率的函数。我们的结果表明，纳米孔电阻脉冲方法为微凝胶通过多孔膜的渗透提供了新的基本见解。
Deformation of 570-nm radius poly(N-isopropylacrylamide-co-acrylic acid) microgels passing through individual 375- to 915-nm radius nanopores in glass has been investigated by the resistive-pulse method. Particle translocation through nanopores of dimensions smaller than the microgel yields electrical signatures reflecting the dynamics of microgel deformation. Translocation rates, and event duration and peak shape, are functions of the conductivities of microgel and electrolyte. Our results demonstrate that nanopore resistive-pulse methods provide new fundamental insights into microgel permeation through porous membranes.