Applications of MicroRNAs in the Diagnosis and Prognosis of Lung Cancer.
Applications of MicroRNAs in the Diagnosis and Prognosis of Lung Cancer.
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DOI：
10.1517/17530059.2012.672970
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Jiang F
中科院分区：
文献类型：
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作者：
Shen J;Jiang F
肺癌是世界范围内癌症死亡的主要原因，由于其诊断较晚且预后较差。MicroRNAs(MiRNAs)是一种小的非编码RNA，通过降解或阻止信使RNA靶标的翻译来调节转录后水平的基因表达。越来越多的证据表明，miRNAs在包括肺癌在内的人类恶性肿瘤的发生发展中起着关键作用。本文综述了1)基于miRNA的生物标记物在肺癌分类中的应用，2)miRNA生物标记物在肺癌早期检测中的应用，以及3)miRNA作为生物标记物预测肺癌预后的应用。MiRNAs为肺癌的诊断和预后提供了有前景的生物标志物。开发的miRNA生物标记物在用于实验室环境之前，应该在临床试验中进行全面和前瞻性的验证。
Lung cancer is the leading cause of cancer death worldwide, due to its late diagnosis and poor outcome. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional levels by either degrading or blocking translation of messenger RNA targets. Accumulating evidence indicates that miRNAs play a pivotal role in the development and progression of human malignancies, including lung cancer. In this review, the authors focus on 1) application of miRNA-based biomarkers to help classify lung cancer, 2) application of the miRNA biomarkers for the early detection of lung cancer, and 3) use of miRNAs as biomarkers to predict outcomes of lung cancer. MiRNAs provide promising biomarkers for the diagnosis and prognosis of lung cancer. The developed miRNA biomarkers should be comprehensively and prospectively validated in clinical trials before being used in laboratory settings.