Biochemical abnormalities in basal ganglia and executive dysfunction in acute- and euthymic-episode patients with bipolar disorder: A proton magnetic resonance spectroscopy study
Biochemical abnormalities in basal ganglia and executive dysfunction in acute- and euthymic-episode patients with bipolar disorder: A proton magnetic resonance spectroscopy study
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双相情感障碍急性期和正常期患者的基底神经节生化异常和执行功能障碍：质子磁共振波谱研究
DOI：
10.1016/j.jad.2017.07.036
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发表时间：
2018-01-01
影响因子：
6.6
通讯作者：
Jia, Yanbin
中科院分区：
文献类型：
--
作者：
Lai, Shunkai;Zhong, Shuming;Jia, Yanbin
背景：近年来研究发现急性双相情感障碍（BD）患者存在生化代谢异常和执行认知功能障碍。然而，有关正常胸腺BD的证据有限。因此，急性和正常胸腺BD之间的比较有助于更好地理解认知和神经影像学结果之间的关联。本研究旨在探讨执行功能和生化代谢之间的关系，在急性和euthymic发作BD患者和描绘的突出endophenotype的BD。方法：三组参与者被招募在本研究中：30 BD患者急性抑郁发作，22 euthymic BD患者，和31名健康对照。所有参与者均使用DSM-IV的结构化临床访谈进行访谈，并进行二维多体素质子磁共振波谱（1H-MRS）以获得基底节（BG）豆状核中的双侧代谢物水平。计算N-乙酰天冬氨酸（NAA）/肌酸（Cr）比值和含胆碱化合物（Cho）/Cr比值。采用威斯康星州卡片分类测验（WCST）和连线测验B部分（TMT-B）评定患者的执行功能。结果：BD患者双侧豆状核NAA/Cr比值明显低于正常对照组（P < 0.05），且急性期和正常期患者的NAA/Cr比值均低于正常对照组（P < 0.05）。
Background: Recent studies found abnormal biochemical metabolism and executive cognitive deficits in acute bipolar disorder (BD). However, the evidence concerning in euthymic BD is limited. Thus, a comparison between acute and euthymic BD is conductive to better understanding the association between cognition and the outcome of neuroimaging. This study sought to investigate the relationship between the executive function and the biochemical metabolism in acute- and euthymic-episode BD patients and delineate the prominent endophenotype of BD.Methods: Three groups of participants were recruited in this study: 30 BD patients with an acute depressive episode, 22 euthymic BD patients, and 31 healthy controls. All participants were interviewed using the Structured Clinical Interview for DSM-IV, and underwent two-dimensional multivoxel proton magnetic resonance spectroscopy (1H-MRS) to obtain the bilateral metabolite levels in the lenticular nucleus of basal ganglia (BG). The ratios of N-acetylaspartate (NAA)/creatine (Cr) and Choline-containing compounds (Cho)/Cr ratios were calculated. Executive function was assessed by using the Wisconsin Card Sorting Test (WCST) and Trail Making Test, Part-B(TMT-B).Results: The comparison of biochemical changes showed that the NAA/Cr ratios in bilateral lenticular nucleus in both acute and euthymic BD patients was significantly lower than that in healthy controls at a confidence level of p