The role of sympathetic and parasympathetic nerve systems on the smooth muscle of rat seminal vesicles – experimental results and speculation for physiological implication on ejaculation
The role of sympathetic and parasympathetic nerve systems on the smooth muscle of rat seminal vesicles – experimental results and speculation for physiological implication on ejaculation
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DOI：
10.1111/j.2047-2927.2013.00146.x
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发表时间：
2014-01
期刊：
影响因子：
4.5
通讯作者：
J. Hsieh;Y. Kuo;H-C Chang;S. Liu;J‐H. Chen;V. Tsai
中科院分区：
文献类型：
--
作者：
J. Hsieh;Y. Kuo;H-C Chang;S. Liu;J‐H. Chen;V. Tsai
射精是一个在不同阶段--射精和射精--产生交感和副交感效应的过程。射精功能障碍的某些情况与自主神经有关。然而，自主神经对射精的确切影响还没有很好的定义。自主神经激动剂诱导不同记录的精囊收缩痕迹模式。不同的轨迹包含不同的相性和紧张性收缩成分，这可能具有生理意义。在本研究中，我们观察了苯肾上腺素(PE)、乙酰胆碱及其各自的拮抗剂对大鼠精囊(SV)的收缩作用，并推测交感神经和副交感神经在射精过程中对SV的生理作用。结果发现，PE和Ach均能使大鼠SV收缩良好。与交感神经的α1b和副交感神经受体的M1、M2相比，α1a和M3是大鼠SV的相对优势亚型。肾上腺素能和胆碱能激动剂引起不同的SV收缩轨迹模式。我们推测，在排出精液的过程中，交感神经作用占主导地位，而在射精过程中，副交感神经作用占主导地位，从而在射精管上提供抗反流作用。
Ejaculation is a process involving sympathetic and parasympathetic effects during different stages – emission and ejection. Some conditions of ejaculation dysfunction are associated with autonomic nerves. However, the exact effects of autonomic nerves on ejaculation are not well defined. Autonomic agonists induce different recorded trace patterns of seminal vesicular contraction. The different traces contain different components of phasic and tonic contraction, which may have physiological implications. In this study, we examined isolated rat seminal vesicle (SV) contraction by phenylephrine (PE), acetylcholine, and their respective antagonists and then speculated upon physiological roles of sympathetic and parasympathetic nerves on SV during ejaculation. We found that PE and Ach both achieved good contraction of rat SV. Compared to α1b for sympathetic and M1, M2 for parasympathetic receptors, α1a and M3 are the relatively dominant subtypes on rat SV. Adrenergic and cholinergic agonists cause different trace patterns of SV contraction. We speculated that the sympathetic effect is dominant during emission to squeeze seminal fluid out and that the parasympathetic effect is dominant during ejection to provide an anti‐reflux effect on the ejaculatory duct.