Fatigue, reduced sleep quality and restless legs syndrome in Charcot-Marie-Tooth disease: a web-based survey
Fatigue, reduced sleep quality and restless legs syndrome in Charcot-Marie-Tooth disease: a web-based survey
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DOI：
10.1007/s00415-009-5390-1
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发表时间：
2010-04-01
影响因子：
6
通讯作者：
Young, Peter
中科院分区：
文献类型：
--
作者：
Boentert, Matthias;Dziewas, Rainer;Young, Peter
研究大型腓骨肌萎缩症（CMT）患者队列中疲劳、日间嗜睡、睡眠质量降低和不宁腿综合征（RLS）的患病率及其对健康相关生活质量（HRQoL）的影响。一项基于网络的调查的参与者回答了埃普沃思嗜睡量表、匹兹堡睡眠质量指数、多维疲劳量表，如果符合RLS的诊断标准，还回答了国际RLS严重程度量表。通过标准化电话访谈，在筛查阳性患者中确认RLS的诊断。使用SF-36问卷评估HRQoL。年龄和性别匹配的对照组受试者从等待手术门诊病人的亲属中招募。227例成人自报CMT患者回答了上述问卷，42.9%为男性，57.1%为女性。年龄18 ~ 78岁。与对照组（n = 234）相比，CMT患者报告了显著更高的疲劳，更高的白天嗜睡程度和患病率以及更差的睡眠质量。CMT患者中RLS的患病率为18.1%，对照组为5.6%（p = 0.001）。RLS严重程度与睡眠质量差和HRQoL降低相关。女性CMT患者比男性患者更容易受到RLS的影响，而且更严重。关于疲劳、睡眠质量、日间嗜睡、RLS患病率、RLS严重程度和HRQoL，我们没有发现遗传上不同的CMT亚型之间存在显著差异。CMT患者的HRQoL降低，这可能是由于疲劳、睡眠相关症状，尤其是RLS。由于CMT的病因治疗是不可用的，睡眠相关的症状应被识别和治疗，以提高生活质量。
To investigate the prevalence of fatigue, daytime sleepiness, reduced sleep quality, and restless legs syndrome (RLS) in a large cohort of patients with Charcot-Marie-Tooth disease (CMT) and their impact on health-related quality of life (HRQoL). Participants of a web-based survey answered the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index, the Multidimensional Fatigue Inventory, and, if the diagnostic criteria of RLS were met, the International RLS Severity Scale. Diagnosis of RLS was affirmed in screen-positive patients by means of a standardized telephone interview. HRQoL was assessed by using the SF-36 questionnaire. Age- and sex-matched control subjects were recruited from waiting relatives of surgical outpatients. 227 adult self-reported CMT patients answered the above questionnaires, 42.9% were male, and 57.1% were female. Age ranged from 18 to 78 years. Compared to controls (n = 234), CMT patients reported significantly higher fatigue, a higher extent and prevalence of daytime sleepiness and worse sleep quality. Prevalence of RLS was 18.1% in CMT patients and 5.6% in controls (p = 0.001). RLS severity was correlated with worse sleep quality and reduced HRQoL. Women with CMT were affected more often and more severely by RLS than male patients. With regard to fatigue, sleep quality, daytime sleepiness, RLS prevalence, RLS severity, and HRQoL, we did not find significant differences between genetically distinct subtypes of CMT. HRQoL is reduced in CMT patients which may be due to fatigue, sleep-related symptoms, and RLS in particular. Since causative treatment for CMT is not available, sleep-related symptoms should be recognized and treated in order to improve quality of life.