Identification of a bioactive compound isolated from Brazilian propolis type 6
Identification of a bioactive compound isolated from Brazilian propolis type 6
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DOI：
10.1016/j.bmc.2009.04.066
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发表时间：
2009-07-15
影响因子：
3.5
通讯作者：
Rosalen, Pedro L.
中科院分区：
文献类型：
--
作者：
Castro, Myrella Lessio;do Nascimento, Andrea Mendes;Rosalen, Pedro L.
从巴西6型蜂胶正己烷馏分中分离得到异丙基二苯甲酮，命名为Hyperibone A，其结构经二维核磁共振波谱确证。该化合物对HeLa肿瘤细胞有较强的细胞毒活性(IC_(50)=0.1756 mU M)，对变形链球菌、远缘链球菌、口腔链球菌、金黄色葡萄球菌和奈氏放线菌有较强的抗菌活性(MIC范围-0.73-6.6mU g/m L，MBC-2.92-106m u g/m L)，其细胞毒性和抗菌效果良好。(C)2009爱思唯尔有限公司。保留所有权利。
A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 mu M), strong antimicrobial activity (MIC range-0.73-6.6 mu g/mL; MBC range-2.92-106 mu g/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good. (C) 2009 Elsevier Ltd. All rights reserved.