Effects of exercise on energy-regulating hormones and appetite in men and women
Effects of exercise on energy-regulating hormones and appetite in men and women
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DOI：
10.1152/ajpregu.90671.2008
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发表时间：
2009-02-01
影响因子：
2.8
通讯作者：
Braun, Barry
中科院分区：
文献类型：
--
作者：
Hagobian, Todd A.;Sharoff, Carrie G.;Braun, Barry
Hagobian TA，Sharoff CG，Stephens BR，Wade GN，Silva JE，Chipkin SR，Braun B.运动对男性和女性能量调节激素和食欲的影响。Am J Physiol Regul Integr Comp Physiol 296：R233-R242，2009。首次发表于2008年12月10日; doi：10.1152/ajpregu.90671.2008。当以前久坐的男性和女性遵循运动训练计划，随意进食时，男性会减掉身体脂肪，但女性不会。这项研究的目的是评估这一观察结果是否与能量调节激素和食欲感知对运动的反应方式的性别差异有关。18名（9名男性，9名女性）超重/肥胖个体完成了四次运动，在基线饮食中添加能量以维持能量平衡（BAL），以及四次运动，没有添加能量以诱导能量不足（DEF）。酰化生长激素释放肽，胰岛素和瘦素的浓度，以及食欲评级，测量后，一餐无运动基线和两种运动条件。在男性中，酰化ghrelin曲线下面积（AUC）在不同条件下没有差异。在女性中，DEF（+ 32%）和BAL（+ 25%）后的酰化ghrelin AUC高于男性（P < 0.05），且较基线的变化高于男性（P < 0.05）。在男性中，DEF后胰岛素AUC降低（-17%）（P < 0.05），但BAL后没有。在女性中，DEF（-28%）和BAL（-15%）后的胰岛素AUC较低（P < 0.05）。两种性别的瘦素浓度在不同条件下没有差异。在男性中，但不是在女性中，食欲被抑制后BAL相对DEF。结果表明，在女性中，运动改变了能量调节激素的方向预期刺激能量摄入，无论能量状态。在男性中，当能量平衡保持时，对运动的反应被取消。这些数据与保持身体脂肪的机制在女性中更有效的范式一致。
Hagobian TA, Sharoff CG, Stephens BR, Wade GN, Silva JE, Chipkin SR, Braun B. Effects of exercise on energy regulating hormones and appetite in men and women. Am J Physiol Regul Integr Comp Physiol 296: R233-R242, 2009. First published December 10, 2008; doi: 10.1152/ajpregu.90671.2008.-When previously sedentary men and women follow exercise training programs with ad libitum feeding, men lose body fat, but women do not. The purpose of this study was to evaluate whether this observation could be related to sex differences in the way energy-regulating hormones and appetite perception respond to exercise. Eighteen (9 men, 9 women) overweight/obese individuals completed four bouts of exercise with energy added to the baseline diet to maintain energy balance (BAL), and four bouts without energy added to induce energy deficit (DEF). Concentrations of acylated ghrelin, insulin, and leptin, as well as appetite ratings were measured in response to a meal after a no-exercise baseline and both exercise conditions. In men, acylated ghrelin area under the curve (AUC) was not different between conditions. In women, acylated ghrelin AUC was higher after DEF (+ 32%) and BAL (+ 25%), and the change from baseline was higher than men (P < 0.05). In men, insulin AUC was reduced (- 17%) after DEF (P < 0.05), but not BAL. In women, insulin AUC was lower (P < 0.05) after DEF (- 28%) and BAL (- 15%). Leptin concentrations were not different across conditions in either sex. In men, but not in women, appetite was inhibited after BAL relative to DEF. The results indicate that, in women, exercise altered energy-regulating hormones in a direction expected to stimulate energy intake, regardless of energy status. In men, the response to exercise was abolished when energy balance was maintained. The data are consistent with the paradigm that mechanisms to maintain body fat are more effective in women.