An overview of Middle East respiratory syndrome coronavirus vaccines in preclinical studies.
An overview of Middle East respiratory syndrome coronavirus vaccines in preclinical studies.
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DOI：
10.1080/14760584.2020.1813574
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发表时间：
2020-09
影响因子：
6.2
通讯作者：
Du L
中科院分区：
文献类型：
--
作者：
Zhang N;Shang J;Li C;Zhou K;Du L
中东呼吸综合征冠状病毒(MERS-CoV)导致人类高死亡率。没有疫苗被批准用于人类；因此，需要始终如一地努力开发安全有效的MERS疫苗。本文介绍了MERS冠状病毒的结构及其蛋白的功能，总结了临床前研究中的MERS候选疫苗(基于尖峰和非尖峰结构蛋白、灭活病毒和减毒活病毒)，并强调了可能阻碍这些疫苗进入临床试验的潜在问题。为开发安全有效的MERS冠状病毒疫苗提供指导。虽然已经开发了许多MERS-CoV疫苗，但大多数仍处于临床前阶段。一些疫苗在动物模型中表现出免疫原性和有效性，而另一些疫苗对高剂量或不同的病毒株具有潜在的不良反应或低效。需要新的策略来设计安全有效的MERS疫苗，以诱导广谱免疫反应，并提高对多种MERS冠状病毒株和具有大流行潜力的MERS样冠状病毒的保护效力。应该投入更多资金，将候选疫苗投入人体临床试验。
Middle East respiratory syndrome coronavirus (MERS-CoV) causes high mortality in humans. No vaccines are approved for use in humans; therefore, a consistent effort to develop safe and effective MERS vaccines is needed. This review describes the structure of MERS-CoV and the function of its proteins, summarizes MERS vaccine candidates under preclinical study (based on spike and non-spike structural proteins, inactivated virus, and live-attenuated virus), and highlights potential problems that could prevent these vaccines entering clinical trials. It provides guidance for the development of safe and effective MERS-CoV vaccines. Although many MERS-CoV vaccines have been developed, most remain at the preclinical stage. Some vaccines demonstrate immunogenicity and efficacy in animal models, while others have potential adverse effects or low efficacy against high-dose or divergent virus strains. Novel strategies are needed to design safe and effective MERS vaccines to induce broad-spectrum immune responses and improve protective efficacy against multiple strains of MERS-CoV and MERS-like coronaviruses with pandemic potential. More funds should be invested to move vaccine candidates into human clinical trials.
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影响因子：
3.7
作者：
Bodmer, Bianca S.;Fiedler, Anna H.;Muehlebach, Michael D.
通讯作者：
Muehlebach, Michael D.
影响因子：
5.5
作者：
Alharbi NK;Padron-Regalado E;Thompson CP;Kupke A;Wells D;Sloan MA;Grehan K;Temperton N;Lambe T;Warimwe G;Becker S;Hill AVS;Gilbert SC
通讯作者：
Gilbert SC
DOI：
10.1074/jbc.m115.700542
发表时间：
2016-03-04
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Cho CC;Lin MH;Chuang CY;Hsu CH
通讯作者：
Hsu CH
沙特阿拉伯骆驼工人中中东呼吸综合征冠状病毒感染率很高
影响因子：
6.4
作者：
Alshukairi AN;Zheng J;Zhao J;Nehdi A;Baharoon SA;Layqah L;Bokhari A;Al Johani SM;Samman N;Boudjelal M;Ten Eyck P;Al-Mozaini MA;Zhao J;Perlman S;Alagaili AN
通讯作者：
Alagaili AN
影响因子：
1.6
作者：
Ababneh, Mustafa;Alrwashdeh, Mu'men;Khalifeh, Mohammad
通讯作者：
Khalifeh, Mohammad