Mortality and cancer incidence in cohorts of Swedish fishermen and fishermen's wives: Updated findings
Mortality and cancer incidence in cohorts of Swedish fishermen and fishermen's wives: Updated findings
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DOI：
10.1016/j.chemosphere.2008.10.006
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发表时间：
2009-02-01
期刊：
影响因子：
8.8
通讯作者：
Rylander, Lars
中科院分区：
文献类型：
--
作者：
Mikoczy, Zoli;Rylander, Lars
目的：鱼类是人体必需物质的重要来源，如n-3 PUFA。然而，某些鱼类也含有相对较高水平的多氯联苯和二恶英。在瑞典，东海岸捕获的脂肪鱼中这些化合物的浓度高于西海岸捕获的鱼。本研究的目的是评估癌症的发病率和死亡率模式之间的队列与当地捕获的鱼从瑞典coasts.Methods摄入量相对较高：队列的渔民和渔民的妻子从瑞典西部和东部海岸。癌症的发病率和死亡率模式进行了评估，到2002年，和原因特异性标准化发病率（SIRs）和死亡率（SMRs）ratios carried out by calculated.Results：低利率的总体死亡率观察到在两个队列从西海岸。我们观察到的发病率低于预期，特别是呼吸道和心血管疾病。东海岸渔民的结肠癌发病率低于预期，而东海岸妻子的结肠癌发病率高于预期。一致增加唇癌的发病率，和海拔的鳞状细胞皮肤癌的发病率，被认为是在渔民cohols.Conclusions：整体死亡率和癌症的发病率低，死亡率低的主要疾病，结肠癌的发病率低，表明一个积极的影响，高饮食鱼类消费量，健康的好处，从一个高度体力活动的工作环境的渔民。日晒是渔民的一种职业危害，不容忽视。(C)2008爱思唯尔有限公司保留所有权利。
Objectives: Intake of fish is an important source for many essential substances, such as n-3 PUFA. However, certain fish also contains relatively high levels of PCBs and dioxins. In Sweden, the concentrations of these compounds are higher in fatty fish caught at the east coast as compared to fish from the west coast. The aim of the present study was to assess cancer incidence and mortality pattern among cohorts with a relatively high intake of locally caught fish from the Swedish coasts.Methods: Cohorts of fishermen and fishermen's wives from the Swedish west and east coasts were established. Cancer incidence and mortality patterns were assessed up to year 2002, and cause-specific standardised incidence (SIRs) and mortality (SMRs) ratios were calculated.Results: Low rates for overall mortality were observed in the two cohorts from the west coast. We observed lower than expected rates especially for respiratory and cardiovascular diseases. Incidence of colon cancer was lower than expected among the east coast fishermen and higher than expected among the east coast wives. Consistently increased incidence of lip cancer, and an elevation of the squamous cell skin cancer incidence, was seen in the fishermen cohorts.Conclusions: The low rates for overall mortality and cancer incidence, and low death rates for major diseases, and the low colon cancer incidence, indicates a positive impact of high dietary fish consumption, and health benefits from a highly physically active work environment for the fishermen. Sun exposure as an occupational hazard among fishermen should not be neglected. (C) 2008 Elsevier Ltd. All rights reserved.