DHEAS patterning across childhood in three sub-Saharan populations: Associations with age, sex, ethnicity, and cortisol
DHEAS patterning across childhood in three sub-Saharan populations: Associations with age, sex, ethnicity, and cortisol
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DOI：
10.1002/ajhb.23090
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发表时间：
2018-03-01
影响因子：
2.9
通讯作者：
Meehan, Courtney L.
中科院分区：
文献类型：
--
作者：
Helfrecht, Courtney;Hagen, Edward H.;Meehan, Courtney L.
目的激素在人类个体发育中有许多作用，包括生活史转换点的时间。有限的激素数据存在于非西方儿童中，这使得我们对生活史模式多样性的理解存在重大差距。本横断面研究探讨硫酸脱氢表雄酮（DHEAS）的生产与年龄，性别，种族，皮质醇浓度，以及肾上腺初显的平均年龄，阿卡和Ngandu儿童的中非共和国和Sidama儿童的Ethiopia.MethodsHair收集了480名儿童（160每人口），年龄3- 18岁。使用ELISA分析这些样本的DHEAS和皮质醇浓度。一个广义的加法模型被用来检查DHEAS图案与年龄，性别，皮质醇，种族。DHEAS作为年龄的函数的衍生物被用来确定肾上腺初显在每个population.ResultsDHEAS图案在这三个人群中的平均年龄是不同的欧美模式的生产。在所有这三个组中，人口水平的年龄在adrenarche发病稍晚于欧美平均水平，与中非人口经历了较晚的发病比埃塞俄比亚population.ConclusionsDHEAS模式和年龄在adrenarche不同的文化，也许表明适应性生活史的反应在不同的生态文化环境。胎儿区的延迟退化和DHEAS模式可能在高风险，营养不良的环境中提供认知保护和免疫防御。在大多数世界的额外研究是必不可少的，以提高我们的理解的多样性激素的发展和时间的开关点'在生活史的轨迹。
ObjectivesHormones have many roles in human ontogeny, including the timing of life history switch points' across development. Limited hormonal data exist from non-Western children, leaving a significant gap in our understanding of the diversity of life history patterning. This cross-sectional study examines dehydroepiandrosterone sulfate (DHEAS) production in relation to age, sex, ethnicity, and cortisol concentrations, as well as average age of adrenarche, among Aka and Ngandu children of the Central African Republic and Sidama children of Ethiopia.MethodsHair was collected from 480 children (160 per population) aged 3-18years old. These samples were analyzed for DHEAS and cortisol concentrations using ELISAs. A generalized additive model was used to examine DHEAS patterning in relation to age, sex, cortisol, and ethnicity. The derivative of DHEAS as a function of age was used to identify average age of adrenarche in each population.ResultsDHEAS patterning in these three populations is distinct from Euro-American patterns of production. In all three groups, the population-level age at adrenarche onset occurs slightly later than Euro-American averages, with both Central African populations experiencing a later onset than the Ethiopian population.ConclusionsDHEAS patterns and age at adrenarche vary across cultures, perhaps indicating adaptive life history responses in diverse eco-cultural environments. Delayed involution of the fetal zone and DHEAS patterning may offer both cognitive protection and immune defense in high-risk, nutritionally-poor environments. Additional research in the majority world is essential to improving our understanding of the diversity of hormonal development and timing of switch points' in life history trajectories.