Thyroid hormones: positive relationships with cognition in healthy, euthyroid older men.
Thyroid hormones: positive relationships with cognition in healthy, euthyroid older men.
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DOI：
10.1093/gerona/54.3.m111
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发表时间：
1999-03
期刊：
影响因子：
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通讯作者：
Patricia N. Prinz;J. Scanlan;P. Vitaliano;K. Moe;Soo Borson;Bert Toivola;George R. Merriam;Lawrence H. Larsen;H. Reed
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文献类型：
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作者：
Patricia N. Prinz;J. Scanlan;P. Vitaliano;K. Moe;Soo Borson;Bert Toivola;George R. Merriam;Lawrence H. Larsen;H. Reed
虽然临床甲状腺功能减退与认知功能障碍的关系是众所周知的，但甲状腺激素对正常甲状腺受试者的认知作用的研究和了解较少。本研究的目的是检查甲状腺功能正常的健康老年男性的甲状腺认知关系。方法：研究对象为健康男性（N = 44，平均年龄= 72），排除临床甲状腺功能减退/甲状腺功能亢进或糖尿病/高血糖患者，以及痴呆、抑郁症、中枢神经系统药物或近期疾病患者。收集24小时内获得的血浆样本，然后检测总甲状腺素（TT4）、总三碘甲状腺原氨酸（TT3）和T3树脂摄取。计算游离甲状腺素指数（FT4I）。对所有受试者进行广泛的认知测试（包括韦氏成人智力量表修订版[WAIS-R]、痴呆评定量表[DRS]和Rivermead行为量表[Profile]）。结果控制年龄和受教育程度的回归分析显示，TT4和FT4I与整体认知测量呈显著正相关；在综合认知测量（如WAIS表现、WAIS语言评分和全球认知评分）中，TT4占8%至12%的差异。结论：我们的研究结果表明，在“正常”的血浆甲状腺激素变化范围内，TT4与健康老年男性的一般认知呈正相关，而T3与一般认知呈正相关。
BACKGROUND Although the association of clinical hypothyroidism with cognitive deficits is well known, the cognitive effects of thyroid hormones in euthyroid subjects are less studied and understood. The purpose of this study was to examine thyroid-cognition relationships in healthy, euthyroid older men. METHODS We examined healthy men (N = 44, mean age = 72), excluding clinically hypothyroid/hyperthyroid or diabetic/hyperglycemic subjects and those with dementia, depression, CNS medications, or recent illness. Plasma samples obtained across a 24-hour period were pooled, then assayed for total thyroxine (TT4), total triiodothyronine (TT3), and T3 resin uptake. Free thyroxine index (FT4I) was calculated. A broad cognitive battery (including the Wechsler Adult Intelligence Scale-Revised [WAIS-R], the Dementia Rating Scale [DRS], and the Rivermead Behavioral Profile [PROFILE]) was administered to all subjects. RESULTS Regression analyses controlling age and education showed TT4 and FT4I to have significant positive relationships with measures of overall cognition; TT4 accounted for 8% to 12% of the variance in omnibus cognitive measures such as WAIS Performance, WAIS Verbal score, and GLOBAL cognitive scores. CONCLUSIONS Our findings suggest that within "normal" range of variation in plasma thyroid hormones, TT4 but not T3 positively associates with general cognition in healthy elderly men.