EXPRESSION OF IMMUNE SYSTEM-ASSOCIATED ANTIGENS BY CELLS OF THE HUMAN CENTRAL NERVOUS-SYSTEM - RELATIONSHIP TO THE PATHOLOGY OF ALZHEIMERS-DISEASE
EXPRESSION OF IMMUNE SYSTEM-ASSOCIATED ANTIGENS BY CELLS OF THE HUMAN CENTRAL NERVOUS-SYSTEM - RELATIONSHIP TO THE PATHOLOGY OF ALZHEIMERS-DISEASE
复制标题
DOI：
10.1016/s0197-4580(88)80079-4
复制
发表时间：
1988-07-01
影响因子：
4.2
通讯作者：
CIVIN, WH
中科院分区：
文献类型：
--
作者：
ROGERS, J;LUBERNAROD, J;CIVIN, WH
HLA-DR是一种II类主要组织相容性复合体抗原，在外周具有抗原递呈能力。我们之前的研究表明，这种标记物在老年人和阿尔茨海默病（AD）患者的皮层中大量表达，就像淋巴因子白细胞介素-2的受体一样。我们现在报告了AD中存在额外的免疫相关抗原，以及与正常老年人对照的分布差异。在灰质中，HLA-DR免疫反应性通常是稀疏的，除了阿尔茨海默病，它几乎与所有的神经斑块共定位。HLA-DR阳性的T细胞可以在阿尔茨海默病的脑组织中被证实，也可以在假定的脑小胶质细胞和T细胞之间发生对抗。此外，还观察到具有星形细胞标记自然杀伤细胞抗原（Leu-11）的形态学特征的细胞，以及明显携带T辅助细胞和T细胞毒性/抑制细胞抗原的淋巴细胞。这些和其他数据表明，阿尔茨海默病的神经胶质增生和清道夫活性特征可能发生在免疫环境中，并可能在疾病的发病机制中发挥重要作用。
HLA-DR is a class II major histocompatibility complex antigen which in the periphery confers antigen presenting capability. We have previously shown that this marker is profusely expressed in cortex of elderly and Alzheimer''s disease (AD) patients, as is the receptor for the lymphokine interleukin-2. We now report presence of additional immune-related antigens in AD, and distributional differences from normal elderly controls. In gray matter, HLA-DR immunoreactivity is normally sparse, except in AD where it co-localizes with virtually all neuritic plaques. HLA-DR positive T cells can be demonstrated in Alzheimer''s disease brain tissue, as can instances of apposition between putative brain microglia and T cells. In addition, cells with the morphologic characteristics of astrocytes label for natural killer cell antigen (Leu-11), and apparent lymphocytes bearing T helper and T cytotoxic/suppressor cell antigens are observed. These and other data suggest that the glial proliferation and scavenger activity characteristic of Alzheimer''s disease may occur in an immune context and may play an important role in the pathogenesis of the disorder.