Association of insulin resistance with anti-Mullerian hormone levels in women without polycystic ovary syndrome (PCOS)
Association of insulin resistance with anti-Mullerian hormone levels in women without polycystic ovary syndrome (PCOS)
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DOI：
10.1111/j.1365-2265.2009.03614.x
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发表时间：
2010-01-01
影响因子：
3.2
通讯作者：
Kim, Tak
中科院分区：
文献类型：
--
作者：
Park, Hyun T.;Cho, Geum J.;Kim, Tak
P>ObjectiveTo explore the relationship of insulin resistance (IR) and adipokines (leptin, adiponectin, RBP4) to anti-Mullerian hormone (AMH) levels in women without polycystic ovary syndrome (PCOS).Design/patients/measurementsWe recruited 120 healthy, reproductive age women without PCOS. An overnight fasting blood draw, anthropometric measurements, analyses of serum levels of AMH, adipokines (leptin, adiponectin and RBP4) and total testosterone, a homeostasis model assessment for insulin resistance (HOMA-IR) and a transvaginal ultrasound scan were performed between the third and fifth day of their spontaneous menstrual cycles.ResultsHigher HOMA-IR levels were associated with lower levels of AMH. After adjustment for age, serum AMH levels negatively correlated with insulin, fasting glucose, HOMA-IR and RBP4. However, a positive correlation was identified between serum AMH and adiponectin. A final multiple stepwise linear regression demonstrated that HOMA-IR was independently associated with AMH.ConclusionAn independent relationship exists between HOMA-IR and AMH in women without PCOS, possibly due to the effect of abnormal insulin action on AMH secretion by granulosa cells.
