Effects of PCBs and PBDEs on thyroid hormone, lymphocyte proliferation, hematology and kidney injury markers in residents of an e-waste dismantling area in Zhejiang, China.
Effects of PCBs and PBDEs on thyroid hormone, lymphocyte proliferation, hematology and kidney injury markers in residents of an e-waste dismantling area in Zhejiang, China.
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DOI：
10.1016/j.scitotenv.2015.07.025
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发表时间：
2015-12
期刊：
影响因子：
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通讯作者：
Peiwei Xu;Xiao-ming Lou;Gang-qiang Ding;Haitao Shen;Lizhi Wu;Zhijian Chen;Jian-long Han;Xiaofeng Wang
中科院分区：
文献类型：
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作者：
Peiwei Xu;Xiao-ming Lou;Gang-qiang Ding;Haitao Shen;Lizhi Wu;Zhijian Chen;Jian-long Han;Xiaofeng Wang
多氯联苯（PCBs）和多溴联苯醚（PBDEs）是电子废物拆解环境中释放的两类典型污染物。在中国，多氯联苯和多溴联苯醚的身体负担与电子废物拆解场人群的甲状腺激素异常有关，但结果有限且相互矛盾。在这项研究中，我们测量了40名居民在电子废物拆解区和15名居民在对照区的多氯联苯和多溴联苯醚和甲状腺激素游离三碘甲状腺原氨酸（FT 3），游离甲状腺素（FT 4）和促甲状腺激素（TSH）的血清水平。同时检测淋巴细胞增殖指标、血液学指标和肾损伤标志物，包括白色细胞、中性粒细胞、单核细胞、淋巴细胞、血红蛋白、血小板、血肌酐和β 2-微球蛋白（β2-MG）。结果表明，接触组的多氯联苯平均水平显著高于对照组（964.39和67.98 ng g− 1，p< 0.0001），但接触组的多溴二苯醚平均水平并不显著高于对照组（139.32对75.74 ng g− 1，p> 0.05）。暴露组血清FT_3、FT_4、单核细胞和淋巴细胞水平显著降低，而中性粒细胞、血红蛋白、血小板和血清肌酐水平显著升高（p< 0.05）。PCBs与FT 3、FT 4、单核细胞、淋巴细胞呈负相关（p< 0.05），与中性粒细胞、血红蛋白、血肌酐、β2-MG呈正相关（p< 0.05）。此外，多溴联苯醚的平均水平与白色血细胞、血红蛋白和血小板的水平呈正相关（p< 0.05）。我们的数据表明，暴露于电子废物拆解环境可能会增加本地居民体内多氯联苯和特定多溴二苯醚同系物的负担，电子废物释放的污染物可能会导致甲状腺激素，血液学和肾损伤标志物的身体水平发生异常变化。
Polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are two typical categories of contaminants released from e-waste dismantling environments. In China, the body burdens of PCBs and PBDEs are associated with abnormal thyroid hormones in populations from e-waste dismantling sites, but the results are limited and contradictory. In this study, we measured the serum levels of PCBs and PBDEs and the thyroid hormone free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) in 40 residents in an e-waste dismantling area and in 15 residents in a control area. Additionally, we also measured some lymphocyte proliferation indexes, hematologic parameters and kidney injury markers, including white blood cells, neutrophils, monocytes, lymphocytes, hemoglobin, platelets, serum creatinine and beta 2-microglobulin (β2-MG). The results indicated that the mean level of ΣPCBs in the exposure group was significantly higher than that in the control group (964.39 and 67.98 ng g− 1,p< 0.0001), but the mean level of ΣPBDEs in the exposure group was not significantly higher than that in the controls (139.32 vs. 75.74 ng g− 1,p> 0.05). We determined that serum levels of FT3, FT4, monocytes and lymphocytes were significantly lower, whereas the levels of neutrophils, hemoglobin, platelets and serum creatinine were significantly higher in the exposed group (p< 0.05). The mean level of ΣPCBs was negatively correlated with levels of FT3, FT4, monocytes and lymphocytes (p< 0.05) and positively correlated with levels of neutrophils, hemoglobin, serum creatinine and β2-MG (p< 0.05). Additionally, the mean level of ΣPBDEs was positively correlated with levels of white blood cells, hemoglobin and platelets (p< 0.05). Our data suggest that exposure to an e-waste dismantling environment may increase the body burdens of PCBs and the specific PBDEs congeners in native residents and that the contaminants released from e-waste may contribute to abnormal changes in body levels of thyroid hormone, hematology and kidney injury markers.