Spatiotemporal characteristics of pain-associated neuronal activities in primary somatosensory cortex induced by peripheral persistent nociception
Spatiotemporal characteristics of pain-associated neuronal activities in primary somatosensory cortex induced by peripheral persistent nociception
复制标题
外周持续性伤害感受引起的初级体感皮层疼痛相关神经元活动的时空特征。
DOI：
10.1016/j.neulet.2008.08.090
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发表时间：
2008-12-19
影响因子：
2.5
通讯作者：
Chen, Jun
中科院分区：
文献类型：
--
作者：
Chang, Ying;Yan, Lai-Hong;Chen, Jun
初级体感皮层（SI区）是躯体有害信息中枢加工产生痛觉的关键脑结构之一。然而，到目前为止，对外周持续性伤害感觉相关神经元活动的时空特征研究甚少。在本报告中，我们使用c-Fos作为神经元标记物，分析大鼠皮下注射蜂毒（BV）溶液（一种成熟的持续疼痛动物模型）后SI区疼痛相关神经元活动的时空模式。在未处理和盐处理的大鼠中，c- fos标记神经元在S1区后肢区呈弥漫性和稀疏性分布。注射sc . BV后，c- fos标记的神经元在表层（VIII）密集增加，在深层（IV-VI）增加较少。第II-III层c-Fos阳性神经元的平均数量在第I h开始增加，在BV处理后2 h达到峰值，之后逐渐减少。c-Fos在IV-VI层表达的时间过程与浅层平行，但密度和量级都要低得多。目前的研究结果表明，bv诱导的外周持续性伤害可以引起SI区神经元活动的增加，并主要定位于II-III层。(C) 2008年由爱思唯尔爱尔兰有限公司出版
The primary somatosensory cortex (SI area) is one of the key brain structures for central processing of somatic noxious information to produce pain perception. However, so far, the spatiotemporal characteristics of neuronal activities associated with peripheral persistent nociception have rarely been studied. In the present report, we used c-Fos as a neuronal marker to analyze spatial and temporal patterns of pain-related neuronal activities within the SI area of rats subjecting to subcutaneous (s.c.) injection of bee venom (BV) solution, a well-established animal model of persistent pain. In naive and saline-treated rats, c-Fos-labeled neurons were diffusely and sparsely distributed in the hindlimb region of S1 area. Following s.c. BV injection, c-Fos-labeled neurons became densely increased in superficial layers (VIII) and less increased in deep layers (IV-VI). The mean number of c-Fos positive neurons in the layers II-III began to increase at I h and reached a peak at 2 h after BV treatment that was followed by a gradual decrease afterward. The time course of c-Fos expression in the layers IV-VI was in parallel with that of the superficial layers, but with a much lower density and magnitude. The present results demonstrated that BV-induced peripheral persistent nociception Could evoke increased neuronal activities in the SI area with predominant localization in layers II-III. (C) 2008 Published by Elsevier Ireland Ltd.