Analysis of the genetic association between IL27 variants and coronary artery disease in a Chinese Han population.
Analysis of the genetic association between IL27 variants and coronary artery disease in a Chinese Han population.
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中国汉族人群IL27变异与冠心病的遗传关联分析
DOI：
10.1038/srep25782
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发表时间：
2016-05-12
影响因子：
4.6
通讯作者：
Cheng X
中科院分区：
文献类型：
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作者：
Fan Q;Nie S;Li S;Liao Y;Zhang H;Zha L;Wang F;Tang T;Xia N;Xu C;Wang P;Xie T;Xie J;Lu Q;Li Q;Qian J;Li B;Wu G;Wu Y;Yang Y;Wang QK;Tu X;Cheng X
白细胞介素-27 （IL-27）是包括冠状动脉疾病（CAD）在内的炎症性疾病的重要细胞因子。为了探索IL-27在CAD中的确切作用，我们在中国汉族人群中研究了IL-27与CAD之间的遗传关联。对3075例CAD病例和2802例对照进行了两阶段病例对照关联分析。采用Logistic回归分析对CAD的传统危险因素进行校正。结果显示，在发现人群中，启动子变异rs153109倾向于与CAD存在边际相关性（Padj = 0.028, OR = 1.27, 95%CI: 1.03-1.58）。然而，在验证阶段没有重复这种关联（Padj = 0.559, OR = 1.04, 95%CI: 0.90-1.21）。此外，当我们根据发病年龄或疾病状态将合并人群分为两个亚组时，我们再次发现没有显著相关性。最后，我们使用Gensini评分系统估计冠状动脉狭窄的严重程度，并确定rs153109基因型仍然与CAD患者的Gensini评分无关。总之，我们的研究未能发现中国汉族人群中IL-27功能区域的常见变异与CAD之间的关联，这表明IL-27可能只是CAD发展过程中的炎症标志物。
Interleukin-27 (IL-27) is an important cytokine in inflammatory diseases, including coronary artery disease (CAD). To explore the precise role of IL-27 in CAD, we investigated the genetic association between IL27 and CAD in the GeneID Chinese Han population. A two-stage case control association analysis was performed for 3075 CAD cases and 2802 controls. Logistic regression analysis was used to adjust the traditional risk factors for CAD. Results showed that a promoter variant, rs153109, tended to be marginally associated with CAD in the discovery population (Padj = 0.028, OR = 1.27, 95%CI: 1.03–1.58). However, this association was not replicated in the validation stage (Padj = 0.559, OR = 1.04, 95%CI: 0.90–1.21). In addition, when we classified the combined population into two subgroups according to the age at disease onset or disease state, we again obtained no significant associations. Finally, we estimated the severity of coronary stenosis using the Gensini Scoring system and determined that the rs153109 genotypes were still not associated with the Gensini scores of the CAD patients. In conclusion, our study failed to find an association between common variants in the functional region of IL27 and CAD in a Chinese Han population, which indicated that IL-27 might only be an inflammatory marker during the development of CAD.