Unstable neurons underlie a stable learned behavior
Unstable neurons underlie a stable learned behavior
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DOI：
10.1038/nn.4405
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发表时间：
2016-12-01
影响因子：
25
通讯作者：
Gardner, Timothy J.
中科院分区：
文献类型：
--
作者：
Liberti, William A., III;Markowitz, Jeffrey E.;Gardner, Timothy J.
运动技能可以保持几十年，但这种记忆持久性的生物学基础在很大程度上仍然未知。例如，斑胸草雀会唱一种高度定型的歌，这种歌可以稳定多年，但我们不知道，这种歌背后的精确神经模式是稳定的，还是每天都在变化。在这里，我们证明了运动前核（HVC）中编码歌曲的投射神经元的数量每天都在变化。最剧烈的变化发生在睡眠的间歇期。与兴奋性神经元的短暂参与相反，以抑制为主的集合测量即使在下游运动神经受损后也保持不变。这些观察结果提供了一个运动稳定性的原理：当直接驱动行为的主要神经元数量从一天到下一天发生变化时，抑制的时空模式可以为运动动力学维持一个稳定的支架。
Motor skills can be maintained for decades, but the biological basis of this memory persistence remains largely unknown. The zebra finch, for example, sings a highly stereotyped song that is stable for years, but it is not known whether the precise neural patterns underlying song are stable or shift from day to day. Here we demonstrate that the population of projection neurons coding for song in the premotor nucleus, HVC, change from day to day. The most dramatic shifts occur over intervals of sleep. In contrast to the transient participation of excitatory neurons, ensemble measurements dominated by inhibition persist unchanged even after damage to downstream motor nerves. These observations offer a principle of motor stability: spatiotemporal patterns of inhibition can maintain a stable scaffold for motor dynamics while the population of principal neurons that directly drive behavior shift from one day to the next.