Effects of prostaglandins E2 and F2 alpha on electromyogram of cat colon in vitro.
Effects of prostaglandins E2 and F2 alpha on electromyogram of cat colon in vitro.
复制标题
前列腺素E2和F2α对体外猫结肠肌电图的影响。
DOI：
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发表时间：
1996
影响因子：
3.1
通讯作者：
S. Anuras
中科院分区：
文献类型：
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作者：
J. Conklin;S. Anuras
前列腺素引起腹泻，在腹泻状态下肠道产生的前列腺素增加。我们研究了PGF 2 α和PGE 2对体外猫结肠记录的肌电图的影响，以确定这些前列腺素是否可能产生类似于结肠炎状态下的肌电图变化。PGF2 α降低了近端结肠的慢波频率和非耦合慢波传播。它增加了迁移性棘波爆发的频率。PGE_2对慢波无影响，但增加了迁移性棘波爆发的频率。PGF 2 α产生的肌电图变化与自发性腹泻猫结肠记录的变化或暴露于蓖麻油酸酯或奎尼丁等产麻剂后的变化相似。一些产生前列腺素的药物可能通过增加前列腺素的产生而起作用。
Prostaglandins cause diarrhea, and their production by the gut increases in diarrheal states. We studied the effects of PGF2 alpha and PGE2 on the electromyogram recorded from the cat colon in vitro to determine if these prostaglandins might produce electromyographic changes similar to those seen in diarrheal states. PGF2 alpha decreased slow wave frequency and uncoupled slow wave propagation in the proximal colon. It increased the frequency of migrating spike bursts. PGE2 had no effect on slow waves, but increased the frequency of the migrating spike burst. PGF2 alpha produced electromyographic changes similar to those recorded from the colon of cats with spontaneous diarrhea or after exposure to diarrhea-producing agents such as ricinoleate or quinidine. Some diarrhea-producing agents are likely to act by increasing prostaglandin production.