Cooperative Photoredox- and Nickel-Catalyzed Alkylative Cyclization Reactions of Alkynes with 4-Alkyl-1,4-dihydropyridines
Cooperative Photoredox- and Nickel-Catalyzed Alkylative Cyclization Reactions of Alkynes with 4-Alkyl-1,4-dihydropyridines
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光氧化还原和镍协同催化炔烃与 4-烷基-1,4-二氢吡啶的烷基化环化反应
DOI：
10.1021/acs.joc.1c01018
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Nishibayashi Yoshiaki
中科院分区：
文献类型：
--
作者：
Zhang Yulin;Tanabe Yoshiaki;Kuriyama Shogo;Nishibayashi Yoshiaki
在可见光照射下，碘代炔与4-烷基-1，4-二氢吡啶的光氧化还原和镍催化的烷基化环化反应得到了相应的烷基化亚环戊基，产率较高。在碘代炔炔的炔丙基位置引入取代基，导致立体选择性地形成E-异构体。该反应体系提供了一种新型的光氧化还原和镍催化协同作用下端炔和内炔的烷基化环化反应的合成方法。
Cooperative photoredox- and nickel-catalyzed alkylative cyclization reactions of iodoalkynes with 4-alkyl-1,4-dihydropyridines as alkylation reagents under visible light irradiation have been achieved to afford the corresponding alkylated cyclopentylidenes in good to high yields. Introduction of substituents at the propargylic position of iodoalkynes has led to the stereoselective formation ofE-isomers. The present reaction system provides a novel synthetic method for alkylative cyclization reactions of both terminal and internal alkynes with cooperative photoredox and nickel catalysis.