Linear differentiation of cytotoxic effectors into memory T lymphocytes
Linear differentiation of cytotoxic effectors into memory T lymphocytes
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DOI：
10.1126/science.283.5408.1745
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发表时间：
1999-03-12
期刊：
影响因子：
56.9
通讯作者：
Ashton-Rickardt, PG
中科院分区：
文献类型：
--
作者：
Opferman, JT;Ober, BT;Ashton-Rickardt, PG
免疫学中的一个中心问题是长寿T细胞记忆的起源，它提供了防止复发感染的保护。研究了转NAI：VE T细胞受体基因的CD8(+)细胞向效应细胞毒性T淋巴细胞(CTL)和记忆性CD8(+)细胞的分化。强烈抗原刺激后产生的CD8(+)记忆细胞是细胞毒效应细胞的后代，过继转移给无抗原受体小鼠10周后仍保留抗原特异性细胞杀伤活性。因此，基于CTL记忆的潜在疫苗将需要将原始细胞分化为效应后记忆T细胞。
A central question in immunology is the origin of Long-Lived T cell memory that confers protection against recurrent infection. The differentiation of nai:ve T cell receptor transgenic CD8(+) cells into effector cytotoxic T Lymphocytes (CTLs) and memory CD8(+) cells was studied. Memory CD8(+) cells that were generated after strong antigenic stimulation were the progeny of cytotoxic effecters and retained antigen-specific cytolytic activity 10 weeks after adoptive transfer to antigen-free recipient mice. Thus, potential vaccines based on CTL memory will require the differentiation of naiive cells into post-effector memory T cells.