Agonistic behavior during stress prevents the development of learned helplessness in rats
Agonistic behavior during stress prevents the development of learned helplessness in rats
复制标题
应激期间的竞争行为可防止大鼠习得性无助的发展
DOI：
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发表时间：
1998
影响因子：
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通讯作者：
E. Vinogradova
中科院分区：
文献类型：
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作者：
D. A. Zhukov;E. Vinogradova
雄性Wistar大鼠在单独或成对的笼子中受到不可避免的电疼痛刺激。在实验过程中，受到压力的老鼠成双成对地打架。48小时后，在穿梭箱中测试大鼠产生主动回避反应的能力。单独应激大鼠的逃避和回避反应比例明显低于正常应激大鼠和成对应激大鼠。1天后、休息时和给药地塞米松后测定血浆皮质酮。各组动物的静息皮质酮水平无显著差异。给药地塞米松显著降低了正常大鼠和成对应激大鼠的血浆皮质酮水平，但在单独应激大鼠中没有。因此，在不可避免的压力下，拮抗行为阻止了适应性行为和内分泌系统病理变化的发展。
Male Wistar rats were subjected to unavoidable electrical pain stimulation either in individual cages or in pairs. During the procedure, rats stressed in pairs fought. After 48 h, rats were tested in a shuttle box for the ability to develop active avoidance responses. The proportion of escape and avoidance responses was significantly lower in rats stressed individually as compared with intact animals and animals stressed in pairs. Plasma corticosterone was assayed one day later, at rest and aftere dexamethasone administration. There were no significant differences in resting corticosterone levels between groups of animals. Administration of dexamethasone significantly reduced the plasma corticosterone level in intact rats and in animals stressed in pairs, but not in rats stressed individually. Thus, agonistic behavior during unavoidable stress prevents the development of pathological changes in adaptive behavior and the endocrine system.