Microbial Consortia Engineering for Cellular Factories: in vitro to in silico systems.
Microbial Consortia Engineering for Cellular Factories: in vitro to in silico systems.
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DOI：
10.5936/csbj.201210017
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发表时间：
2012
影响因子：
6
通讯作者：
Carlson RP
中科院分区：
文献类型：
--
作者：
Bernstein HC;Carlson RP
这篇简短的评论讨论了实验和计算微生物财团工程的现状，重点是细胞工厂。讨论有前途的生态理论为中心的社区资源利用，以方便解释财团设计。最近的案例研究，举例说明不同的资源使用图案和财团组装模板。该审查还强调了在硅片的方法来设计和分析财团的化学计量建模方法的重点。微生物联合体工程学科具有广泛接受的潜力，可以产生高度新颖和有效的生物催化剂，用于从生物燃料到特种化学品到提高矿物回收率的应用。
This mini-review discusses the current state of experimental and computational microbial consortia engineering with a focus on cellular factories. A discussion of promising ecological theories central to community resource usage is presented to facilitate interpretation of consortial designs. Recent case studies exemplifying different resource usage motifs and consortial assembly templates are presented. The review also highlights in silico approaches to design and to analyze consortia with an emphasis on stoichiometric modeling methods. The discipline of microbial consortia engineering possesses a widely accepted potential to generate highly novel and effective bio-catalysts for applications from biofuels to specialty chemicals to enhanced mineral recovery.