Effect of oral hydration on skin microcirculation in healthy young and midlife and older adults.
Effect of oral hydration on skin microcirculation in healthy young and midlife and older adults.
复制标题
口服补水对健康年轻人、中年人和老年人皮肤微循环的影响。
DOI：
10.1111/j.1524-475x.2007.00202.x
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Williams,DonnaA
中科院分区：
文献类型：
--
作者：
Wipke-Tevis,DeidreD;Williams,DonnaA
临床上未发现的水分不足会降低皮下组织的含氧量，损害愈合并增加伤口感染。这项研究考察了补充口服补水对健康成年人皮肤温度(Ts)、经皮皮肤O2(PtCO2)和CO2(PtcCO2)以及皮肤血流量(激光多普勒流量计[通量]=运动血细胞浓度[CMBC]×流速)的非侵入性测量的影响。19名对照组和18名试验组(含水)受试者参加了试验。实验前允许自由摄取液体。传感器被放置在胸部、小腿和脚上。取第1次仰卧位TS、PTCO_2/PtcCO_2、流量/CmBC/Velocity。然后，试验组摄取500 毫升的水。30min后测时间2次。数据分析采用方差分析。TS、PtCO2、PtcCO2和速度的变化在不同组之间没有差异。与对照组相比，试验组通量增加更多(p<；0.01)。通量的变化可以通过CMBC的增加来解释(p<；0.05)。仅对于中年/老年受试者，测试中的CMBC变化大于对照组(p<；0.01)。流量可能足够敏感，可以检测到补充口服补水后微血管的变化。这些数据还表明，在自然状态下居住在社区的健康中年人/老年人中，可能存在由于水分不足而导致的微妙程度的低灌流。
Clinically undetected underhydration lowers subcutaneous tissue oxygen, impairs healing and increases wound infection. This study examined the effect of supplemental oral hydration on noninvasive measures of skin temperature (Ts), transcutaneous skin O2(PtcO2), and CO2(PtcCO2), and skin blood flow (laser Doppler fluxmetry [Flux]=concentration of moving blood cells [CMBC] × Velocity) in healthy adults. Nineteen Control and 18 Test (Hydrated) subjects participated. Ad libitum fluid intake was allowed before the experiment. Sensors were placed on the chest, lower legs, and feet. Time 1 resting supine Ts, PtcO2/PtcCO2, and Flux/CMBC/Velocity were obtained. Then, the Test group ingested 500 mL of H2O. Time 2 measures were obtained 30 minutes later. Data were analyzed using ANOVA. Change in Ts, PtcO2, PtcCO2, and Velocity did not differ between groups. Flux increased more in the Test than in the Control group (p<0.01). The Flux change was explained by a CMBC increase (p<0.05). For midlife/older subjects only, the CMBC change was greater in the Test than in the Control group (p<0.01). Flux may be sufficiently sensitive to detect microvascular changes in response to supplemental oral hydration. These data also suggest that subtle levels of hypoperfusion due to underhydration may exist in community‐dwelling healthy midlife/older adults in their natural state.