Bacteroiades thetaiotaomicron:: a dynamic, niche-adapted human symbiont
Bacteroiades thetaiotaomicron:: a dynamic, niche-adapted human symbiont
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DOI：
10.1002/bies.10350
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发表时间：
2003-10-01
期刊：
影响因子：
4
通讯作者：
Coyne, MJ
中科院分区：
文献类型：
--
作者：
Comstock, LE;Coyne, MJ
人类与其肠道微生物群落的共同进化导致了合作关系，这些合作关系塑造了这些共生伙伴的生物学和基因组。多形拟杆菌是一种这样的细菌共生体，其是人类和其他哺乳动物的肠道微生物群的主要成员。本文报道了B.多形微生物是首次报道的人类结肠微生物群中丰富的革兰氏阴性生物，因此，提供了在基因组规模上对革兰氏阴性共生体在该生态系统中占主导地位所使用的遗传武器库的第一次一瞥。基因组已经揭示了许多旁系同源基因组的大量扩增，这些基因编码生物体在这种环境中成功竞争的能力所必需的产物。最值得注意的是生物体的丰富机制，利用各种复杂的多糖作为碳和能量的来源。蛋白质组还揭示了生物体适应和调节其基因表达以应对不断变化的生态系统的广泛能力。这些因素，以及下面强调的其他因素，表明一个令人难以置信的灵活性和适应性的有机体，具有精美的装备，可以在其具有挑战性和竞争力的利基市场中占据主导地位。BioEssays 25：926- 929，2003。(C)2003 Wiley Periodicals，Inc.
The coevolution of humans with their intestinal microflora has resulted in cooperative relationships that have shaped the biology and the genomes of these symbiotic partners. Bacteroides thetaiotaomicron is one such bacterial symbiont that is a dominant member of the intestinal microbiota of humans and other mammals. The recent report of the genome sequence of B. thetaiotaomicron(l) is the first reported for an abundant Gram-negative organism of the human colonic microbiota and, as such, provides the first glimpse on a genomic scale of the genetic arsenal used by a Gram-negative symbiont to dominate in this ecosystem. The genome has revealed large expansions of many paralogous groups of genes that encode products essential to the organism's ability to successfully compete in this environment. Most noteable is the organism's abundant machinery for utilizing a large variety of complex polysaccharldes as a source of carbon and energy. The proteome also reveals the organism's extensive ability to adapt and regulate expression of its genes in response to the changing ecosystem. These factors, as well as others highlighted below, suggest an incredibly flexible and adaptable organism that is exquisitely equipped to dominate in its challenging and competitive niche. BioEssays 25:926-929,2003. (C) 2003 Wiley Periodicals, Inc.