Psychosocial functioning in patients with treatment resistant depression.
Psychosocial functioning in patients with treatment resistant depression.
复制标题
难治性抑郁症患者的心理社会功能。
DOI：
10.1016/j.eurpsy.2003.11.006
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Nierenberg,AndrewA
中科院分区：
文献类型：
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作者：
Petersen,Timothy;Papakostas,GeorgeI;Mahal,Yasmin;Guyker,WendyM;Beaumont,ErinC;Alpert,JonathanE;Fava,Maurizio;Nierenberg,AndrewA
抑郁症是一种导致残疾的疾病，对社会心理功能的所有领域都有深远的不利影响。对于那些患有难治性抑郁症（TRD）的人来说尤其如此。然而，迄今为止，尚未对TRD患者的社会心理功能进行系统评估。方法采用纵向间隔随访评估（LIFE）量表对92例TRD患者的心理社会功能进行测评。这些患者符合TRD的正式标准，是检验去甲替林锂增强疗效的临床试验的一部分。结果：临床医生认为这些患者在工作相关活动中有轻度到中度损害，人际关系良好到公平，娱乐活动参与程度较差，享受性活动的能力有轻度损害。患者和临床医生认为全球社会适应能力差。结论正式定义的TRD患者存在显著的社会心理功能障碍。在这个样本中，与特定功能区域的评分相比，临床医生和患者都倾向于分配更严重受损的整体评分。
BackgroundDepression is a disorder that causes disability, with a profound adverse impact on all areas of psychosocial functioning. This is particularly true for those with treatment resistant depression (TRD). However, to date, no systematic assessments of psychosocial functioning for patients with TRD have been conducted.MethodsIn the present study, we used the Longitudinal Interval Follow-up Evaluation (LIFE) scale to measure psychosocial functioning in 92 patients with TRD. These patients met formal criteria for TRD and were part of a clinical trial examining the efficacy of lithium augmentation of nortriptyline.ResultsClinicians rated this sample of patients as experiencing mild to moderate impairment in work-related activities, good to fair interpersonal relations, poor level of involvement in recreational activities, and mild impairment of ability to enjoy sexual activity. Patients and clinicians rated global social adjustment as poor.ConclusionsPatients with formally defined TRD experience significant impairment in psychosocial functioning. In this sample a tendency existed for both clinicians and patients to assign more severely impaired global ratings when compared with ratings for specific functional areas.