Effect of Rhizoma coptidis (Huang Lian) on Treating Diabetes Mellitus.
Effect of Rhizoma coptidis (Huang Lian) on Treating Diabetes Mellitus.
复制标题
黄连治疗糖尿病的作用
DOI：
10.1155/2015/921416
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Tong XL
中科院分区：
文献类型：
--
作者：
Pang B;Yu XT;Zhou Q;Zhao TY;Wang H;Gu CJ;Tong XL
糖尿病（diabetes mellitus，DM）的迅速增长正成为全球性的重大公共卫生问题，西方降糖药和胰岛素的研究取得了长足的进展，但仍存在不足。中医药作为补充和替代疗法的重要组成部分，在糖尿病的治疗中发挥了良好的临床作用，显示出广阔的发展前景。中医药治疗具有一定的毒副作用小的优势，而中草药通常含有多种有效成分，可以提供多种治疗效果。黄连（Rhizoma copyrium，RC）是亚洲传统方剂中常用的中药，具有“清湿热、熄火、解毒”的功效。本文从两个方面的内容对RC在糖尿病治疗中的应用进行综述。本文首先阐述了中药复方的理论基础，包括中药复方的性质及相关文献记载，以及中药复方及其有效成分的现代药理学研究和药代动力学研究。其次，重点综述了RC的临床应用，包括RC的适用阶段和证候、合理剂量范围、制剂剂型、毒副作用及解决方法。本文就RC的有效成分、药理研究、毒性等方面进行综述，并介绍中医药理论和临床经验，以期指导临床更合理、更恰当地使用RC。
The rapidly increasing diabetes mellitus (DM) is becoming a major public health issue globally; considerable progress has been made in the field of western hypoglycemic drug and insulin, but some shortages still exist. As one of the most important parts in complementary and alternative therapies, traditional Chinese medicine (TCM) performs a good clinical practice and is showing a bright future in the treatment of DM. TCM therapy has certain advantages of less toxicity and/or side effects, and Chinese herbal medicine which usually contains various active ingredients could provide multiple therapeutic effects. Huang Lian (Rhizoma coptidis, RC) is a herb frequently used in many traditional formulas for properties of “clearing damp-heat, quenching fire, and counteracting poison” in Asia for centuries. In this review, we summarize the application of RC in the treatment of DM from two aspects of contents. Firstly, theoretical principles are explained, including the properties and related records about RC in ancient references and modern pharmacological researches and pharmacokinetics on RC and its active components. Secondly, the clinical application of RC is mainly reviewed, such as applicable stage and syndrome, the reasonable dose range, the preparation formulations, and the toxicity and/or side effects and solutions to its adverse actions. This review provides scientific evidence about the effective components, pharmacological researches, and toxicity of RC, as well as introducing traditional Chinese medical theory and clinical experience, in order to guide clinician to use RC more suitably and reasonably in the clinical practice.