New developments in lung endothelial heterogeneity: Von Willebrand factor, P-selectin, and the Weibel-Palade body.
New developments in lung endothelial heterogeneity: Von Willebrand factor, P-selectin, and the Weibel-Palade body.
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DOI：
10.1055/s-0030-1253452
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发表时间：
2010-04
影响因子：
5.7
通讯作者：
Stevens T
中科院分区：
文献类型：
--
作者：
Ochoa CD;Wu S;Stevens T
静止的肺内皮建立了一个抗血栓形成，抗炎表面，促进血液流动。然而，内皮通过促进血栓形成并使炎性细胞（如嗜中性粒细胞）定向迁移到肺泡气隙中来快速响应损伤和炎症。虽然负责建立促血栓形成表面的内皮细胞信号与负责识别循环中性粒细胞的内皮细胞信号不同，但这些过程高度相关。血管性血友病因子刺激的分泌在血栓形成中起重要作用，而P-选择素表面表达在中性粒细胞结合中起关键作用。血管性血友病因子和P-选择素均位于肺动脉和小动脉的韦伯-帕拉德小体内，而毛细血管中则不存在韦伯-帕拉德小体。尽管没有韦伯-帕拉德小体，肺毛细血管表达血管性血友病因子和P-选择素。这些观察结果的生理和病理生理意义尚不清楚。在这篇综述中，我们讨论了一些解剖和生理特征，区分肺动脉，毛细血管和静脉内皮。此外，我们回顾了我们目前的理解有关的血管性血友病因子和P-选择素在肺动脉和毛细血管内皮细胞的刺激分泌。这一信息被认为是在血管炎和肺炎的情况下，两个病理生理过程中，刺激分泌的血管性血友病因子和P-选择素的贡献。
Quiescent pulmonary endothelium establishes an anti-thrombotic, anti-inflammatory surface that promotes blood flow. However, the endothelium rapidly responds to injury and inflammation by promoting thrombosis and enabling the directed transmigration of inflammatory cells, such as neutrophils, into the alveolar airspace. While the endothelial cell signals responsible for establishing a pro-thrombotic surface are distinct from those responsible for recognizing circulating neutrophils, these processes are highly inter-related. Von Willebrand factor stimulated secretion plays an important role in thrombus formation, while P-selectin surface expression plays a key role in neutrophil binding necessary for transmigration. Both von Willebrand factor and P-selectin are located within Weibel-Palade bodies in pulmonary arteries and arterioles, yet Weibel-Palade bodies are absent in capillaries. Despite the absence of the Weibel-Palade bodies, pulmonary capillaries express both von Willebrand factor and P-selectin. The physiological and pathophysiological significance of these observations is unclear. In this review, we address some anatomic and physiologic features that distinguish pulmonary artery, capillary, and vein endothelium. In addition, we review our current understanding regarding the stimulated secretion of von Willebrand factor and P-selectin in pulmonary artery and capillary endothelium. This information is considered in the context of vasculitis and pneumonia, two pathophysiological processes to which the stimulated secretion of von Willebrand factor and P-selectin contribute.
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DOI：
10.1073/pnas.1434429100
发表时间：
2003-09-16
影响因子：
11.1
作者：
Chi, JT;Chang, HY;Brown, PO
通讯作者：
Brown, PO
DOI：
10.1152/ajplung.00316.2007
发表时间：
2008-03-01
影响因子：
4.9
作者：
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影响因子：
3.1
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Stevens, Troy
影响因子：
4.8
作者：
Forlow, SB;Foley, PL;Ley, K
通讯作者：
Ley, K
DOI：
10.1152/ajplung.1999.277.1.l119
发表时间：
1999-07-01
影响因子：
4.9
作者：
Stevens, T;Creighton, J;Thompson, WJ
通讯作者：
Thompson, WJ