Uncertainty Analysis of Ventricular Mechanics Using the Probabilistic Collocation Method

Uncertainty Analysis of Ventricular Mechanics Using the Probabilistic Collocation Method
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使用概率配置方法进行心室力学的不确定性分析

DOI:
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发表时间:
2012
影响因子:
4.6
通讯作者:
J. Sundnes
J. Sundnes
中科院分区:
工程技术2区
文献类型:
--
作者:
H. Osnes;J. Sundnes

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材料参数的不确定性和可变性是计算生物力学的基本挑战。用参数扫描或蒙特卡罗方法分析和量化计算结果中的不确定度在计算上已经变得非常困难。在本文中,我们考虑了一种称为概率配置法的随机方法,并探讨了它在计算左心室被动力学行为中的不确定性分析中的适用性。具体地说,我们研究了材料输入参数的不确定性对响应特性的影响,如腔体积的增加、脑室的延长、内径的增加、壁厚的减少和心尖处的旋转。本文进行的数值模拟表明,该方法非常适合于所考虑的问题,并且在获得详细的不确定度量化方面比蒙特卡罗模拟法要有效得多。数值实验还给出了有趣的迹象,表明哪些材料参数对于准确确定各种全球响应最关键。
Uncertainty and variability in material parameters are fundamental challenges in computational biomechanics. Analyzing and quantifying the resulting uncertainty in computed results with parameter sweeps or Monte Carlo methods has become very computationally demanding. In this paper, we consider a stochastic method named the probabilistic collocation method, and investigate its applicability for uncertainty analysis in computing the passive mechanical behavior of the left ventricle. Specifically, we study the effect of uncertainties in material input parameters upon response properties such as the increase in cavity volume, the elongation of the ventricle, the increase in inner radius, the decrease in wall thickness, and the rotation at apex. The numerical simulations conducted herein indicate that the method is well suited for the problem of consideration, and is far more efficient than the Monte Carlo simulation method for obtaining a detailed uncertainty quantification. The numerical experiments also give interesting indications on which material parameters are most critical for accurately determining various global responses.
DOI: 10.1115/1.2891194
发表时间: 1990-08-01
影响因子: 1.7
作者:
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通讯作者: YIN, FCP
DOI: 10.1113/jphysiol.1983.sp014738
发表时间: 1983-01-01
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