Interleukin 16 in pregnancy, parturition, rupture of fetal membranes, and microbial invasion of the amniotic cavity
Interleukin 16 in pregnancy, parturition, rupture of fetal membranes, and microbial invasion of the amniotic cavity
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DOI：
10.1016/s0002-9378(00)70502-3
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发表时间：
2000-01-01
影响因子：
9.8
通讯作者：
Edwin, SS
中科院分区：
文献类型：
--
作者：
Athayde, N;Romero, R;Edwin, SS
目的：白介素16是一种促炎细胞因子，能促进非克隆型T细胞和嗜酸性粒细胞向炎症部位募集，并诱导抵抗激活诱导的细胞凋亡。这种多肽与趋化因子家族的成员没有同源性，由上皮细胞产生。目前还没有关于这种细胞因子在人类怀孕期间表达的信息。本研究旨在确定羊水中是否存在白介素16，以及分娩和宫内感染对这种细胞因子浓度的影响。研究设计：230例妇女分为以下几组：(1)中期妊娠组(n=25)；(2)足月未分娩组(n=25)；(2)足月未分娩组(n=25)；(4)早产胎膜早破伴羊膜腔微生物入侵29例和无微生物侵入23例。采用灵敏、特异的羊水免疫分析法检测血清白介素16浓度。结果：(1)87.8%(202/230)的羊水标本中检测到IL-16。(2)中期孕妇羊水中白介素16浓度显著高于足月未分娩孕妇(中位数，321.5 pg/m L；范围：146.9-1185.8 pg/m l；与中位数，85.9pg/m l；
OBJECTIVE: Interleukin 16 is a proinflammatory cytokine that promotes the recruitment of nonclonotypic T cells and eosinophils to sites of inflammation and induces resistance to activation-induced apoptosis. This peptide has no homology with members of the chemokine family and is produced by epithelial cells. No information is available about the expression of this cytokine during human pregnancy. This study was conducted to determine whether interleukin 16 is present in amniotic fluid and to examine the effects of labor and intrauterine infection on the concentrations of this cytokine.STUDY DESIGN: A cross-sectional study was constructed with 230 women in the following groups: (1) midtrimester (n = 25); (2) term not in labor (n = 25), term in labor (n = 25), and term premature rupture of membranes not in labor (n = 40); (3) preterm labor and intact membranes with (n = 21) and without (n = 42) intra-ammiotic infection; and (4) preterm premature rupture of membranes in the presence (n = 29) and absence (n = 23) of microbial invasion of the amniotic cavity. Interleukin 16 concentration was measured with sensitive and specific immunoassays validated for amniotic fluid. Data were analyzed with nonparametric statistics.RESULTS: (1) Interleukin 16 was detected in 87.8% (202/230) of amniotic fluid samples. (2) Amniotic fluid interleukin 16 concentrations were significantly higher in women in the midtrimester than in those at term not in labor (median, 321.5 pg/mL; range, 146.9-1185.8 pg/mL; vs median, 85.9 pg/mL; range,