Cardiac involvement in systemic lupus erythematosus
Cardiac involvement in systemic lupus erythematosus
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DOI：
10.1191/0961203305lu2200oa
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发表时间：
2005-01-01
期刊：
影响因子：
2.6
通讯作者：
Petri, M
中科院分区：
文献类型：
--
作者：
Doria, A;Iaccarino, L;Petri, M
心包炎是系统性红斑狼疮（SLE）患者最常见的心脏病变，但瓣膜、心肌和冠状血管均可发生病变。在过去，心脏病的表现是严重的，危及生命，往往导致死亡。因此，它们经常在验尸中被发现。现在心脏病的表现往往是轻微的和无症状的。然而，它们可以通过超声心动图和其他非侵入性检查来识别。超声心动图是检测心脏异常，特别是轻度心包炎、瓣膜病变和心肌功能障碍的敏感和特异性技术。因此，超声心动图应定期检查SLE患者。血管炎、过早的动脉粥样硬化或SLE相关的抗磷脂抗体可能导致血管闭塞，包括冠状动脉。早期动脉粥样硬化是SLE患者中最常见的冠状动脉疾病（CAD）原因。应努力控制传统的危险因素以及可能导致动脉粥样硬化斑块发展的所有其他因素。
Pericarditis is the most common cardiac abnormality in systemic lupus erythematosus (SLE) patients, but lesions of the valves, myocardiurn and coronary vessels may all occur. In the past, cardiac manifestations were severe and life threatening, often leading to death. Therefore, they were frequently found in post-mortem examinations. Nowadays cardiac manifestations are often mild and asymptomatic. However, they can be frequently recognized by echocardiography and other noninvasive tests. Echocardiography is a sensitive and specific technique in detecting cardiac abnormalities, particularly mild pericarditis, valvular lesions and myocardial dysfunction. Therefore, echocardiography should be performed periodically in SLE patients. Vascular occlusion, including coronary arteries, may develop due to vasculitis, premature atherosclerosis or antiphospholipid antibodies associated with SLE. Premature atherosclerosis is the most frequent cause of coronary artery disease (CAD) in SLE patients. Efforts should be made to control traditional risk factors as well as all other factors which could contribute to atherosclerotic plaque development.