Magnetic sensitivity enhanced novel fluorescent magnetic silica nanoparticles for biomedical applications
Magnetic sensitivity enhanced novel fluorescent magnetic silica nanoparticles for biomedical applications
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DOI：
10.1088/0957-4484/19/7/075610
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发表时间：
2008-02-20
期刊：
影响因子：
3.5
通讯作者：
Haam, Seungjoo
中科院分区：
文献类型：
--
作者：
Yang, Jaemoon;Lee, Jaewon;Haam, Seungjoo
我们合成了新型的荧光磁性二氧化硅纳米粒子（FMSNPs）含有大的磁性组件的生物医学应用。通过采用磁性纳米颗粒组装体作为针对FMSNPs的核，磁化强度和磁共振（MR）信号强度均显著增强。此外，通过在FMSNPs表面上引入正电荷来改善FMSNPs的细胞结合，并且FMSNPs表面上的荧光染料使得能够对亚细胞区域进行光学成像。
We synthesized novel fluorescent magnetic silica nanoparticles (FMSNPs) containing large magnetic components for biomedical application. By employing assemblies of magnetic nanoparticles as kernels against FMSNPs, both the saturation of magnetization and the magnetic resonance (MR) signal intensity were significantly enhanced. Furthermore, the cellular binding of FMSNPs was improved by introducing a positive charge on the surface of the FMSNPs, and fluorescent dyes on the surface of FMSNPs enable optical imaging of sub-cellular regions.