Heart rate variability and autonomic nerve activities in ambulatory dogs.
Heart rate variability and autonomic nerve activities in ambulatory dogs.
复制标题
行走犬的心率变异性和自主神经活动。
DOI：
10.1109/iembs.2006.259925
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Lin,Shien-Fong
中科院分区：
文献类型：
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作者：
Song,Juan;Ogawa,Masahiro;Tan,AlexY;Chen,Peng-Sheng;Lin,Shien-Fong
心率变异性分析是研究植物神经系统交感神经和副交感神经功能的重要方法。虽然这样的分析可以提供自主神经活动的定量估计，神经活动和ECG的同时记录将允许更直接的调查心率的神经调制。我们开发了一种方法，允许直接和长期记录的神经活动和心电图使用无线设备植入在走动的狗。本研究的目的是探讨自主神经放电和心率变异性之间的关系。在这项研究中，连续5天评估HRV和神经活动。通过计算24小时内心搏间期的平均值和标准差来评估HRV。神经活动是通过在200 Hz高通滤波以去除ECG干扰之后的滤波整流的神经信号的总和来获得的。显示HRV作为交感神经和迷走神经活动的函数的图将提供对正常和患病心脏中心率的神经调节的重要见解。
Analysis of heart rate variability is a valuable method to investigate the sympathetic and parasympathetic function of the autonomic nervous system. Although such analyses can provide quantitative estimates of autonomic neural activity, simultaneous recording of neural activities and ECG will allow more direct investigation of neural modulation of heart rate. We developed a method that allows direct and long-term recording of neural activities and ECG using wireless device implanted in ambulatory dogs. The aim of this study was to investigate the relationship between autonomic neural firing and heart rate variability. In this study, HRV and neural activities were assessed for 5 continuous days. HRV was evaluated by calculating the mean and the standard deviation of inter-beat intervals in 24 hours. Neural activities were obtained by the sum of the filtered rectified neural signals after 200 Hz high-pass filtering to remove ECG interference. The plots showing HRV as a function of both the sympathetic and vagal activities will offer significant insights into neural modulation of heart rate in normal and diseased hearts.