Plasma ghrelin concentrations in different clinical stages of diabetic complications and glycemic control in Japanese diabetics
Plasma ghrelin concentrations in different clinical stages of diabetic complications and glycemic control in Japanese diabetics
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DOI：
10.1507/endocrj.k07-007
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发表时间：
2007-12-01
影响因子：
2
通讯作者：
Mondal, Muhtashan S.
中科院分区：
文献类型：
--
作者：
Ueno, Hiroaki;Shilya, Tomomi;Mondal, Muhtashan S.
Ghrelin是一种由28个氨基酸组成的酰化肽，可刺激食物摄入、GH分泌和胃动力。实验研究表明，ghrelin在葡萄糖稳态、动脉粥样硬化和微血管病中起作用。我们研究了生长激素释放肽可能参与糖尿病患者的微血管和大血管糖尿病并发症和血糖控制。分别在108例和61例日本糖尿病患者中测量了空腹和餐后血浆ghrelin浓度。血浆ghrelin浓度与体重指数（BMI）（r=-0.309，P =0.002）或HbA 1c（r=-0.264，P =0.0065）呈负相关。血清肌酐水平（s-Cre）升高的糖尿病肾病患者血浆ghrelin水平显著高于s-Cre正常的患者（P
Ghrelin is an acylated 28-amino-acid peptide that stimulates food intake, GH secretion, and gastric motility. Experimental studies have suggested that ghrelin plays roles in glucose homeostasis, atherosclerosis, and microangiopathy. We investigated possible involvement of ghrelin in micro- and macro-vascular diabetic complications and glycemic control in diabetic patients. Fasting and postprandial plasma ghrelin concentrations after a test meal were measured in 108 and 61 Japanese diabetic patients, respectively. Plasma ghrelin concentrations were negatively correlated with body mass index (BMI) (r=-0.309, P=0.002) or HbA(1c) (r=-0.264, P=0.0065). Plasma ghrelin levels in patients with diabetic nephropathy who showed high serum creatinine levels (s-Cre) were significantly higher than those in patients who showed normal s-Cre (P