Salivary Gland Tumors: Use of Intravoxel Incoherent Motion MR Imaging for Assessment of Diffusion and Perfusion for the Differentiation of Benign from Malignant Tumors
Salivary Gland Tumors: Use of Intravoxel Incoherent Motion MR Imaging for Assessment of Diffusion and Perfusion for the Differentiation of Benign from Malignant Tumors
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DOI：
10.1148/radiol.12111248
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发表时间：
2012-06-01
期刊：
影响因子：
19.7
通讯作者：
Nakamura, Takashi
中科院分区：
文献类型：
--
作者：
Sumi, Misa;Van Cauteren, Marc;Nakamura, Takashi
目的：前瞻性地评价体素内非相干运动(IVIM)参数(微血管体积分数，f；纯扩散系数，D；与灌注相关的非相干微循环，D*)用于鉴别涎腺肿瘤的良、恶性。材料和方法：这项前瞻性机构审查委员会批准的研究的所有参与者都提供了书面知情同意。根据IVIM理论，对20例(65%)良性涎腺肿瘤(12例多形性腺瘤和8例沃辛瘤)和11例(35%)恶性涎腺肿瘤的血流灌注和扩散进行了评估。使用11个b值(0-800秒/mm(2))进行磁共振扩散加权成像。结果：涎腺肿瘤的f值(0.156+/-0.039[标准差])明显大于多形性腺瘤(0.066+/-0.031)(P=0.003)。恶性肿瘤的D值(0.96×10(-3)mm(2)/s+/-0.22)与良性肿瘤(多形性腺瘤，1.38×10(-3)mm(2)/s+/-0.30[P=.002]；沃辛瘤(0.61×10(-3)mm(2)/s+/-0.11[P=.005])相比有显著差异。恶性肿瘤的D*值(21.99×10(-3)mm(2)/s+/-19.01)显著小于沃辛瘤(42.64×10(-3)mm(-3)mm(2)/s+/-20.17)(P=0.022)。结论：IVIM显像有助于涎腺肿瘤的良、恶性鉴别诊断。(C)RSNA，2012年
Purpose: To prospectively evaluate the intravoxel incoherent motion (IVIM) parameters (microvascular volume fraction, f; pure diffusion coefficient, D; and perfusion-related incoherent microcirculation, D*) for differentiating between benign and malignant salivary gland tumors.Materials and Methods: All participants in this prospective institutional review board-approved study provided written informed consent. The perfusion and diffusion of 20 (65%) benign (12 pleomorphic adenomas and eight Warthin tumors) and 11 (35%) malignant salivary gland tumors were assessed on the basis of the IVIM theory. Diffusion-weighted magnetic resonance imaging was performed by using 11 b values (0-800 sec/mm(2)). The IVIM parameters of the salivary gland tumors were determined by a radiologist, and significant differences between the tumor types were assessed by using the Steel-Dwass test.Results: The f values of Warthin tumors (0.156 +/- 0.039 [standard deviation]) were significantly larger than those of pleomorphic adenomas (0.066 +/- 0.031) (P = .003). The D values of malignant tumors (0.96 x 10(-3) mm(2)/sec +/- 0.22) were significantly different from those of benign tumors (pleomorphic adenomas, 1.38 x 10(-3) mm(2)/sec +/- 0.30 [P = .002]; Warthin tumors, 0.61 x 10(-3) mm(2)/sec +/- 0.11 [P = .005]). The D* values of malignant tumors (21.99 x 10(-3) mm(2)/sec +/- 19.01) were significantly smaller than those of Warthin tumors (42.64 x 10(-3) mm(2)/sec +/- 20.17) (P = .022). The combination of D and D* criteria provided the best diagnostic accuracy (100%) for differentiation among the three tumor types.Conclusion: IVIM imaging may be helpful for differentiation between benign and malignant salivary gland tumors. (c) RSNA, 2012