Virulence factors in brucellosis: implications for aetiopathogenesis and treatment
Virulence factors in brucellosis: implications for aetiopathogenesis and treatment
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DOI：
10.1017/s1462399407000543
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发表时间：
2007-12-19
影响因子：
6.2
通讯作者：
Gorvel, Jean-Pierre
中科院分区：
文献类型：
--
作者：
Fugier, Emilie;Pappas, Georgios;Gorvel, Jean-Pierre
布鲁氏菌是全球性人畜共患病布鲁氏菌病的病原。这些细胞内病原体表达一组因子-包括脂多糖，毒力调节蛋白和磷脂酰胆碱-以确保其完全毒力。一些毒力因子对于入侵宿主细胞是必需的，而另一些则是避免被宿主消除的关键。它们允许布鲁氏菌。在其复制泡内存活和增殖，并使细菌能够逃避宿主免疫系统的检测。已经使用了几种策略来开发针对布鲁氏菌病的动物疫苗，但是还没有足够的疫苗来治愈人类的疾病。这可能是由于人类布鲁氏菌复杂的病理生理学。感染，这与动物模型不同。在这里，我们审查布鲁氏菌属。毒力因子以及它们如何控制宿主细胞内的细菌运输。
Brucella species are responsible for the global zoonotic disease brucellosis. These intracellular pathogens express a set of factors - including lipopolysaccharides, virulence regulator proteins and phosphatidylcholine - to ensure their full virulence. Some virulence factors are essential for invasion of the host cell, whereas others are crucial to avoid elimination by the host. They allow Brucella spp. to survive and proliferate within its replicative vacuole and enable the bacteria to escape detection by the host immune system. Several strategies have been used to develop animal vaccines against brucellosis, but no adequate vaccine yet exists to cure the disease in humans. This is probably due to the complicated pathophysiology of human Brucella spp. infection, which is different than in animal models. Here we review Brucella spp. virulence factors and how they control bacterial trafficking within the host cell.